64488-10-4

Upstream product

• 102-49-8 3,4-dichlorobenzyl amine 
• 105-34-0 methyl 2-cyanoacetate 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 64488-25-1 1-(3,4-dichlorobenzyl)-3-cyano-6-methylpyrid-2-one 
• 1415975-92-6 C₁₅H₁₀Cl₂N₂O₂ 
• 1415975-90-4 C₁₅H₁₁Cl₂N₃O 
• 1415976-13-4 C₂₁H₁₄Cl₂N₂O 
• 1415976-12-3 C₁₈H₁₄Cl₂N₂O₂ 
• 1415976-10-1 C₁₇H₁₁Cl₃N₂O 
• 1415976-09-8 C₁₈H₁₄Cl₂N₂O 
• 1415976-15-6 C₂₁H₁₄Cl₂N₂O 
• 1415976-08-7 C₁₇H₁₂Cl₂N₂O 

Relevant academic research and scientific papers

Focused library development of 2-phenylacrylamides as broad spectrum cytotoxic agents

With our lead compound (E)-3-(4-chlorophenyl)-2-(1H-pyrrole-2-carbonyl) acrylonitrile (1) inducing 50% growth inhibition of 11 cancer cell lines at 27-61 μM, potency enhancements were rapidly established through the synthesis of a series of focused compou

Modulators of LXR

Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of nuclear receptors, including liver X receptor (LXR) and orphan nuclear receptors. In certain embodiments, the compounds are N-substituted pyridones.

α-Cyanocinnamide derivatives: A new family of non-peptide, non-sulfhydryl inhibitors of ras farnesylation

Farnesylation of Ras and other proteins is required for their membrane attachment and normal function. Here we report on the synthesis of α-cyanocinnamide derivatives, a new family of farnesyltransferase inhibitors. These compounds are nonpeptidic and do not contain sulfhydryl groups. The most potent compound is a pure competitive inhibitor with respect to the Ras protein and mixed competitive with respect to farnesyl diphosphate. Selectivity studies against geranylgeranyltransferase and biological activities of selected compounds are described. Copyright (C) 1999.

Derivatives of 3-carboxy pyrid-2-ones

Novel compounds belonging to the class of 1-substituted benzylpyrid-2-one-4,6-dialkyl and 4,5,6-trisubstituted-3-carboxylic acids, amides, esters and physiologically acceptable salts. These compounds possess biological activity and in particular are gametocides and plant growth regulators. Novel 1-substituted benzyl-3-cyano-4,5,6-trisubstituted pyrid-2-ones are also disclosed as intermediates.