64490-46-6 Usage
General Description
1-(chloromethyl)-2-iodo-3,4,5-trimethoxybenzene is a chemical compound with the molecular formula C10H12ClIO3. It is a benzene derivative with three methoxy groups and one chloromethyl and one iodo group attached to the benzene ring. 1-(chloromethyl)-2-iodo-3,4,5-trimethoxybenzene is often used in organic synthesis and medicinal chemistry as a reagent or intermediate for the production of various pharmaceuticals and agrochemicals. The presence of the iodo and chloromethyl groups make it a versatile building block for the synthesis of complex organic molecules. Additionally, the trimethoxy groups can influence the compound's physical and chemical properties, making it useful for various applications in industry and research.
Check Digit Verification of cas no
The CAS Registry Mumber 64490-46-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,4,9 and 0 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 64490-46:
(7*6)+(6*4)+(5*4)+(4*9)+(3*0)+(2*4)+(1*6)=136
136 % 10 = 6
So 64490-46-6 is a valid CAS Registry Number.
64490-46-6Relevant articles and documents
Cycloadditions of 4-pyrones. An approach to colchicine
McBride,Garst
, p. 2839 - 2854 (2007/10/02)
The 4-pyrone, [5-acetoxy-4-oxo-4H-pyran-2-yl]carbonyl chloride was coupled with the malonate anion of bis(2,2,2-trichloroethyl) 2-ethenyl-3,4,5-trimethoxybenzylpropanedioate and analogs thereof. These adducts then underwent intramolecular thermal cyclizations (61-100% yield) to form the two fused seven member rings of the carbon skeleton of colchicine. The malonate moiety was deprotected and decarboxylated quantitatively to provide the desired ring system which contained a bridging ether, from C7a to C11 in the C ring, and a ketone at the 7 position. Removal of the bridging ether as H2O would yield the desired tropolone. Our attempts to remove the ether bridge were unsuccessful.
