64490-45-5

Basic information

• Product Name: (2-iodo-3,4,5-trimethoxyphenyl)methanol
• CAS NO: 64490-45-5
• Molecular Formula: C₁₀H₁₃IO₄
• Molecular Weight: 324.1123
• Mol File: 64490-45-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 391.5°C at 760 mmHg
• Flash Point: 190.6°C
• Density: 1.642g/cm³
• Vapor Pressure: 7.85E-07mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: (2-iodo-3,4,5-trimethoxyphenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-iodo-3,4,5-trimethoxyphenyl)methanol(64490-45-5)
• EPA Substance Registry System: (2-iodo-3,4,5-trimethoxyphenyl)methanol(64490-45-5)

Safety Data

• Hazardous Substances Data: 64490-45-5(Hazardous Substances Data)

Usage

General Description

(2-iodo-3,4,5-trimethoxyphenyl)methanol is a chemical compound with the molecular formula C10H13IO4. It is a derivative of phenylmethanol and contains both iodine and methoxy functional groups. (2-iodo-3,4,5-trimethoxyphenyl)methanol is often used in organic synthesis and medicinal chemistry as a building block for the synthesis of various biologically active molecules. It is also a key intermediate in the preparation of pharmaceuticals and agrochemicals. The presence of the iodine and methoxy groups makes this compound useful for introducing specific functional groups into organic molecules, making it a valuable tool for chemical research and drug development.

Upstream product

• 73252-53-6 3,4,5-trimethoxy-2-iodobenzaldehyde 
• 665004-29-5 6,6'-bis(2-iodo-3,4,5-trimethoxybenzyl 1,3-benzodioxole-5-carboxylate) 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 

Downstream Products

• 258283-81-7 6-(6-hydroxymethyl-2,3,4-trimethoxy-phenyl)-benzo[1,3]dioxole-5-carbaldehyde 
• 1189788-41-7 C₁₀H₁₂IN₃O₃ 
• 64490-59-1 Dimethyl-2-Iod-3,4,5-trimethoxybenzylmalonat 
• 117407-47-3 Bis(t-butyl) 2-iodo-3,4,5-trimethoxybenzylpropanedioate 
• 240435-90-9 (6-bromomethyl-2,3,4-trimethoxy-phenylethynyl)-trimethyl-silane 
• 258283-80-6 6-[2,3,4-trimethoxy-6-(2-oxo-2,5-dihydro-furan-3-ylmethyl)-phenyl]-benzo[1,3]dioxole-5-carbaldehyde 
• 258283-82-8 6-(6-bromomethyl-2,3,4-trimethoxy-phenyl)-benzo[1,3]dioxole-5-carbaldehyde 
• 693219-96-4 1-{6-[2,3,4-trimethoxy-6-(2-methoxy-ethoxymethoxymethyl)-phenyl]-benzo[1,3]dioxol-5-yl}-ethanol 
• 638164-11-1 4,4,5,5-tetramethyl-2-(2,3,4-trimethoxy-6-triethylsilanyloxymethyl-phenyl)-[1,3,2]dioxaborolane 
• 638164-04-2 1-[6-(2,3,4-trimethoxy-6-methoxymethoxymethyl-phenyl)-benzo[1,3]dioxol-5-yl]-ethanol 
• 638164-12-2 4,4,5,5-tetramethyl-2-[2,3,4-trimethoxy-6-(2-methoxy-ethoxymethoxymethyl)-phenyl]-[1,3,2]dioxaborolane 

Relevant articles and documents

Pd-catalyzed atom-efficient cross-coupling of triarylbismuth reagents with protecting group-free iodophenylmethanols: Synthesis of biarylmethanols

An atom-efficient procedure for the synthesis of functionalized biarylmethanols via the Pd-catalyzed cross-coupling reactions of differently functionalized iodophenylmethanols and triarylbismuth reagents is described. This protecting group-free direct couplings of 2-, 3- or 4-iodophenylmethanols with triarylbismuth reagents afforded biarylmethanols in good to high yields.

An attempt for biaryl coupling reaction of benzyl benzoate derivatives under Ullmann conditions

The biaryl coupling reaction of benzyl benzoate derivatives (3) and (4) was examined with copper(0) reagent. A dimerized product (9) was mainly obtained whereas the desired intramolecularly coupled product (11) was not detected when 3 was employed as the