64494-09-3Relevant academic research and scientific papers
Gold-Catalyzed Oxidation of Internal Alkynes into Benzils and its Application for One-Pot Synthesis of Five-, Six-, and Seven-Membered Azaheterocycles
Dubovtsev, Alexey Yu.,Dar'in, Dmitry V.,Krasavin, Mikhail,Kukushkin, Vadim Yu.
, p. 1856 - 1864 (2019/02/19)
Internal alkynes have been shown to undergo oxidation to substituted benzils (1,2-diarylethane-1,2-diones) by α-picoline N-oxide in the presence of Ph3PAuNТf2 (5 mol-%). In addition to the unsubstituted benzil, the method allows preparing, under markedly mild conditions (50 °C in chlorobenzene), various non-symmetrical products, including heteroaromatic versions thereof which are much more difficult to obtain otherwise. This gold(I)-catalyzed transformation was integrated into one-pot reaction sequence delivering a range of 5- to 7-membered ring systems (imidazoles, quinoxalines, 1,2,4-triazines, pyrazines, and 1,4-diazepines), thus linking these important heterocyclic motifs to the internal alkyne reagent space.
STUDIES ON as-TRIAZINE DERIVATIVES. X. ADDITION REACTION OF PHENYLMAGNESIUM BROMIDE WITH 1,2,4-TRIAZINES
Konno, Shoetsu,Sagi, Mataichi,Yoshida, Nobuko,Yamanaka, Hiroshi
, p. 3111 - 3114 (2007/10/02)
The reaction of 1,2,4-triazine with phenylmagnesium bromide was investigated.Every position 3,5, and 6 in a 1,2,4-triazine ring is active in the addition reaction of Grignard reagents.Since 5-phenyl-1,2,4-triazine, 5,6-diphenyl-1,2,4-triazine, and 3,5,6-t
