644981-94-2

Basic information

• Product Name: N-BOC-4-(P-CHLOROPHENYL)-4-PIPERIDINE CARBOXYLIC ACID
• Synonyms: N-BOC-4-(P-CHLOROPHENYL)-4-PIPERIDINE CARBOXYLIC ACID;1-(TERT-BUTOXYCARBONYL)-4-(4-CHLOROPHENYL)PIPERIDINE-4-CARBOXYLIC ACID;1-BOC-4-(4-CHLOROPHENYL)-4-PIPERIDINEDICARBOXYLIC ACID;BOC-4-(4-CHLOROPHENYL)-PIPERIDINE-4-CARBOXYLIC ACID;1-Boc-4-(4-chlorophenyl)-4-piperidinecarboxylic acid
• CAS NO: 644981-94-2
• Molecular Formula: C₁₇H₂₂ClNO₄
• Molecular Weight: 339.81
• Mol File: 644981-94-2.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-BOC-4-(P-CHLOROPHENYL)-4-PIPERIDINE CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-4-(P-CHLOROPHENYL)-4-PIPERIDINE CARBOXYLIC ACID(644981-94-2)
• EPA Substance Registry System: N-BOC-4-(P-CHLOROPHENYL)-4-PIPERIDINE CARBOXYLIC ACID(644981-94-2)

Safety Data

• Hazardous Substances Data: 644981-94-2(Hazardous Substances Data)

Usage

General Description

N-BOC-4-(p-chlorophenyl)-4-piperidine carboxylic acid, also known as Boc-piperidine-p-Cl, is a chemical compound used as a building block in organic synthesis. It contains a piperidine ring with a p-chlorophenyl group and a Boc (tert-butyloxycarbonyl) protecting group attached to the nitrogen atom. It is commonly employed in the pharmaceutical industry as a key intermediate in the synthesis of various therapeutic agents and drugs. N-BOC-4-(P-CHLOROPHENYL)-4-PIPERIDINE CARBOXYLIC ACID is also utilized in research and development for the creation of new chemical entities with potential biological activity, making it a valuable tool in medicinal chemistry.

Upstream product

• 140-53-4 p-chlorobenzyl cyanide 
• 91721-16-3 4-(4-chlorophenyl)piperidine-4-carbonitrile 
• 118753-70-1 N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine 
• 218451-34-4 4-(4-chloro-phenyl)-4-cyano-piperidine-1-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 672927-26-3 4-(4-chloro-phenyl)-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester 
• 885500-46-9 tert-butyl 4-(4-chlorophenyl)-4-formylpiperidine-1-carboxylate 
• 917925-59-8 tert-butyl 4-amino-4-(4-chlorophenyl)piperidine-1-carboxylate 
• 644981-95-3 [(3,5-bis-trifluoromethylbenzyl)-methylcarbamoyl]-(4-chlorophenyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 849106-01-0 4-(4-chloro-phenyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-methyl ester 

Relevant articles and documents

Substituted p-chlorophenyl acetylpiperazine-containing compound as well as preparation method and application thereof

The application provides a substituted p-chlorophenyl acetylpiperazine-containing compound as well as a preparation method and application of the substituted p-chlorophenyl acetylpiperazine-containingcompound. The compound has the structure shown in the formula (I), and has better Akt1 inhibitory activity or growth inhibitory activity to MCL cell lines.

A nitrogen-containing heterocyclic phenyl piperidine compound and its preparation method and application

The invention discloses a nitrogen-containing heterocyclic phenyl piperidine compound or pharmaceutical salt thereof. The general structural formula a of the compound is as shown in specification, wherein R represents hydrogen, mono-substituted or poly-substituted halogen, methyl, methoxyl, tertiary butyl or trifluoromethyl; and R2 is hydrogen, chlorine, bromine, methyl or ethyl. The compound disclosed by the invention is novel in structure; and by introducing the active amino in the form of a piperidine ring, the configuration of the side-chain amino is reinforced and the rigidity of the compound is enhanced. Through the design transformation, the Akt1 kinase inhibitory activity and the PC-3 cell line growth inhibitory activity of the compound are significantly enhanced.

CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF

Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.