64505-93-7Relevant academic research and scientific papers
A One-Pot Approach to 2-(N-Substituted Amino)-1,4-naphthoquinones with Use of Nitro Compounds and 1,4-Naphthoquinones in Water
Chen, Xu-Ling,Dong, Yu,He, Shuai,Zhang, Rui,Zhang, Hua,Tang, Lei,Zhang, Xiao-Mei,Wang, Ji-Yu
supporting information, p. 615 - 619 (2019/03/08)
A one-pot synthesis of 2-(N-substituted amino)-1,4-naphthoquinones from 1,4-naphthoquinones and nitro compounds in water has been developed. This method features mild reaction conditions and provides aromatic nitro compounds with various functional groups such as halogens, methylthio, ester, amide, even allyl, propargyl, and heterocycles, as well as aliphatic nitro compounds that are well tolerated. This method can be scaled up and we conducted further transformation of the obtained 2-(N-substituted amino)-1,4-naphthoquinones to synthesize carbazolequinone derivatives.
Method for synthesizing 2-substituted amino-1,4-naphthoquinone derivative
-
Paragraph 0140-0145, (2019/05/28)
The invention discloses a method for synthesizing a 2-substituted amino-1,4-naphthoquinone derivative. The method comprises the following steps: mixing a nitro compound, 2-substituted 1,4-naphthoquinone, a catalyst, a metal and a solvent uniformly at 20-100 DEG C; adding an H source, stirring the components for reaction for 1-24h; performing a reduction-addition reaction between the nitro compoundand the 2-substituted 1,4-naphthoquinone; after the reaction, adding water to the reaction system for dilution; performing filtering; extracting filtrate with ethyl acetate; after organic phases arecombined, washing the mixture with saturated saline solution and drying the mixture with anhydrous sodium sulfate sequentially; subsequently, performing filtering, and performing vacuum concentrationto remove a solvent; and packing solids into a column, and performing separation through column chromatography (a ratio of petroleum ether to ethyl acetate is 5:1) to obtain red solids. Compared withan existing synthesis method, the synthesis method provided by the invention has a wide range of raw materials and the raw materials are easy to obtain; compared with amine compounds, nitro compoundshave better stability; and the synthesis method provided by the invention is simple to operate and mild in reaction condition.
Pd-catalyzed C-H Arylation: A General Route for the Synthesis of Benzo[b]carbazolenaphthoquinones
Mandal, Arabinda,Mondal, Suresh Kumar,Jana, Akash,Manna, Susanta Kumar,Ali, Sk Asraf,Samanta, Shubhankar
, p. 2529 - 2535 (2017/07/25)
A short, efficient and general methodology for benzo[b]carbazolenaphthoquinones was developed via Pd-catalyzed C-H arylation process. This methodology was successfully applied to the synthesis of highly biologically active compound 5H–benzo[b]carbazole-6,
One-Pot Palladium-Catalyzed Synthesis of Benzo[ b ]carbazolediones
Do, Hoang Huy,Tran, Hung Quang,Ohlendorf, Lars,Ngo, Thang Ngoc,Dang, Tuan Thanh,Ehlers, Peter,Villinger, Alexander,Langer, Peter
supporting information, p. 2429 - 2433 (2015/10/19)
A palladium-catalyzed one-pot reaction for the synthesis of benzo[b]carbazolediones is described which proceeds by amination of 2,3-dibromonaphthoquinone, Suzuki cross-coupling with (2-bromophenyl)boronic acid, and subsequent intramolecular C-N Buchwald-H
'On water': unprecedented nucleophilic substitution and addition reactions with 1,4-quinones in aqueous suspension
Tandon, Vishnu K.,Maurya, Hardesh K.
experimental part, p. 5896 - 5902 (2010/01/11)
Unique nucleophilic substitution and addition reactions of 1,4-quinones in aqueous suspension with aromatic amines, primary aliphatic amines, amino acid, ester of amino acid, heterocyclic amines, hydrazine, amide, and thioethers are described in absence o
