6454-01-9

Upstream product

• 1192031-31-4 ethoxycarbonylmethyl 2-(2'-phenylethynyl)phenyl ether 
• 854630-15-2 2-(2-methoxyphenyl)-3-oxo-3-phenylpropanal 
• 59214-70-9 3-bromobenzofuran 
• 113180-51-1 [2-(2-Oxo-2-phenyl-acetyl)-phenoxy]-acetic acid 
• 34589-99-6 2-hydroxybenzil 
• 34082-43-4 2-methoxybenzil 
• 55877-31-1 benzofuran-3-carbonitrile 

Downstream Products

• 68218-56-4 3-(2-phenylbenzofuran-3-yl)propanoic acid 
• 1131341-95-1 3-(2-phenylbenzofuran-3-yl)propionic acid ethyl ester 
• 1131341-92-8 3-(2-phenylbenzofuran-3-yl)propanenitrile 
• 37883-65-1 2-(2-hydroxyphenyl)-1-phenylethan-1-one 
• 1244029-96-6 tert-butyl 3-(2-phenylbenzofuran-3-yl)propanoate 
• 92497-79-5 2-(5-phenyl-isoxazol-4-yl)-phenol 

Relevant academic research and scientific papers

Synthesis of carbonylated heteroaromatic compounds: Via visible-light-driven intramolecular decarboxylative cyclization of o -alkynylated carboxylic acids

An efficient strategy for the easy access to carbonylated heteroaromatic compounds has been developed via a visible-light-promoted intramolecular decarboxylative cyclization reaction of o-alkynylated carboxylic acids. This method is characterized by its b

A novel efficient protocol for preparation of 3-formyl-2-arylbenzo[b]furan derivatives

An efficient method for preparation of 3-formyl-2-arylbenzo[b]furan derivatives 4 from 3-chloro-2-(2-methoxyaryl)-1-arylprop-2-en-1-one 2 was developed, and the desired product was obtained in good to excellent yields. By converting 2-(2-methoxyphenyl)-3-oxo-3-phenylpropanal 1 to 2, the regioselectivity problem occurring in the reaction when using 1 as the starting material was successfully avoided. Furthermore, a one-pot procedure for the successive demethylation, cyclization, and hydrolysis was evolved, although the intermediate 3-(dibromomethyl)-2-phenylbenzo[b]furan 3a could be isolated. A plausible mechanism was proposed based on some in situ investigations.

Intramolecular Ketene Cycloadditions. Synthesis of Isoflavones and 3-Aroylbenzofurans

The conversion of 2-(carboxyalkoxy)benzils to the corresponding phenoxyketenes to an intramolecular ketene cycloaddition to ultimately yield isoflavones and/or 3-aroylbenzofurans.The ketenes may be generated by the classical dehydrochlorination of the acid chloride or by using Perkin reaction conditions, sodium acetate in refluxing acetic anhydride.The initial cycloaddition products are the corresponding β-lactones, which may decarboxylate to the isolated isoflavones and/or 2-aroylbenzofurans.The product distributions are dependent upon the substitution pattern in the orginal benzil acids.