854630-15-2

Upstream product

• 68235-45-0 2,3-epoxy-3-(2-metoxyphenyl)-1-phenylpropan-1-one 
• 135-02-4 ortho-anisaldehyde 

Downstream Products

• 57479-30-8 3-(2-methoxyphenyl)quinoline 
• 1839-72-1 2-phenylbenzofuran 
• 27356-33-8 2-(2-methoxyphenyl)-1-phenylethan-1-one 
• 1610591-71-3 3-(dibromomethyl)-2-phenylbenzo[b]furan 
• 1610591-49-5 (Z)-3-chloro-2-(2-methoxyphenyl)-1-phenylprop-2-en-1-one 
• 37883-64-0 3-(2-phenyl-1-benzofuran)carbaldehyde 
• 6454-01-9 benzofuran-3-yl(phenyl)methanone 

Relevant academic research and scientific papers

An efficient approach to construct 2-arylbenzo[b]furans from 2-methoxychalcone epoxides

An efficient and practical method for construction of 2-arylbenzo[b]furans from 2-methoxychalcone epoxides has been reported. Catalyzed by 2 mol % of BF3·Et2O, 2-methoxychalcone epoxides went through the Meerwein rearrangement, followed by deformylation in one-pot to successfully afforded 2-methoxydeoxybenzoins. Afterward, 2-arylbenzo[b]furans were obtained in high yields (87%-100%) via intermolecular cyclodehydration of 2-methoxydeoxybenzoins with 48% HBr. By utilization of this approach, the natural product stemofuran A and the key intermediate of eupomatenoid 6 have been synthesized conveniently.

Practical approach for preparation of unsymmetric benzils from β-ketoaldehydes

An efficient and practical method for the synthesis of unsymmetric benzils from readily available β-ketoaldehydes has been developed. Various unsymmetric 1,2-diaryldiketones bearing functional groups have been obtained in good to excellent yields under mild reaction conditions. A plausible mechanism was proposed, and α,α-dichloroketone was considered as the key intermediate. The generation of α,α-dichloroketones from β-ketoaldehydes may undergo the following steps: (1) oxidation by sodium hypochlorite, (2) decarboxylation, and (3) chlorination by Cl2 generated from sodium hypochlorite.