64543-31-3Relevant articles and documents
Enantioselective syntheses of (R)- and (S)-argentilactone and their cytotoxic activities against cancer cell lines
De Fatima, ?ngelo,Kohn, Luciana Konecny,Ant?nio, Márcia Aparecida,De Carvalho, Jo?o Ernesto,Pilli, Ronaldo Aloise
, p. 5437 - 5442 (2004)
Concise total syntheses of (R)- and (S)-argentilactone have been developed via enantioselective catalytic allylation (ECA) and ring-closing metathesis pathways. Both enantiomers were obtained in four steps and 39% overall yield and 82-84% ee from 2-octynal. In addition, we present the results of in vitro activity of (R)- and (S)-argentilactone against cancer cell line. Concise total syntheses of (R)- and (S)-argentilactone have been developed via enantioselective catalytic allylation (ECA) and ring-closing metathesis pathways (four steps, 39% overall yield and 82-84% ee) from 2-octynal and their in vitro activity against cancer cells is described.
Asymmetric total syntheses of (R)-(-)-argentilactone and (S)-5-hexadecanolide
Sabitha, Gowravaram,Fatima, Narjis,Swapna,Yadav
, p. 2879 - 2884 (2008/02/05)
The simple and efficient asymmetric syntheses of (R)-(-)-argentilactone and (S)-5-hexadecanolide were achieved from the same starting material by a similar strategy. The key intermediates for both molecules were chiral 5-hydroxyalk-2-en-6-ynoates. Georg T
Synthesis of (R)-(-)-argentilactone
Hansen, Trond Vidar
, p. 547 - 550 (2007/10/03)
A synthesis of (R)-(-)-argentilactone is reported starting from the (S)-enantiomer of glycidol. The synthesis is based on ring closing metathesis of the acrylic ester of (R)-1-O-(tert-butyldiphenylsilyl)-4-penten-1,2-diol 4.
