646-30-0Relevant articles and documents
Ceramides and cytotoxic constituents from Ficus glumosa Del. (Moraceae)
Nana, Fre?de?ric,Sandjo, Louis Pergaud,Keumedjio, Fe?lix,Ambassa, Pantale?on,Malik, Rizwana,Kuete, Victor,Rincheval, Vincent,Choudhary, Muhammad Iqbal,Ngadjui, Bonaventure Tchaleu
, p. 482 - 487 (2012)
Chemical investigation of the stem bark of Ficus glumosa (Moraceae) yielded two new ceramides (2R,7E)-2-hydroxy-N-[(2S,3S,4R)-1,3,4-trihydroxyhexadecan-2- yl]hexacos-7-enamide and (2R)-N-{(2S,3S,4R,9Z)-1-O-[(β-D-glucopyranosyl]-3, 4-dihydroxyheptadec-9-en-2-yl}-2-hydroxypentacosanamide together with twenty one known compounds. The structures were established using NMR data, mass spectrometry, chemical transformation and by comparison with the reported data. Twenty one compounds were further tested against the prostate cancer PC-3 cell line and six of them revealed cytotoxic effect. Dongnoside E was the most active compound with an IC50 0.75 μmol L-1 against the cancer cells line PC-3 while the reference drug doxorubicin displayed 0.91 μmol L-1. This compound also proved to inhibit the cell growth of the fibrosarcoma cancer HT1080 (IC50 0.7 μmol L-1).
The synthesis of a single enantiomer of a major α-mycolic acid of M. tuberculosis
Al Dulayymi, Juma'a R.,Baird, Mark S.,Roberts, Evan
, p. 11939 - 11951 (2007/10/03)
We report a synthesis of a single enantiomer of a mycolic acid from Mycobacterium tuberculosis containing a di-cis-cyclopropane. The method can be simply varied to modify the chain lengths or the absolute stereochemistry of either cyclopropane.
Hair growth composition containing citric acid esters
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, (2008/06/13)
Triesters of citric acid are used for inducing, maintaining or increasing hair growth. Compositions for topical application to mammalian hair or scalp comprise an effective amount of from 1% to 99% by weight of an ester of citric acid having the structure (1): where, R1, R2 and R3 each independently represent a branched or unbranched alkyl, alkenyl, aryl, alkylaryl or arylalkyl group, each said group having from 1 to 18 carbon atoms, R4 represents -H, or a branched or unbranched saturated or unsaturated acyl, alkyl, aryl, alkylaryl or aylalkyl group having from 1 to 18 carbon atoms, in the presence of a cosmetically acceptable vehicle for the citric acid ester and in the absence of solid absorbent for the ester;, said effective amount of said ester being sufficient to increase hair growth in the rat, when said composition is applied topically thereto over a period of no more than three months, by at least 10% more than that obtainable using a control composition from which the said ester has been omitted, in accordance with the Rat Hair Growth Test.
