6460-87-3

Upstream product

• 107-31-3 Methyl formate 
• 101-41-7 benzeneacetic acid methyl ester 
• 108471-63-2 (Z)-3-[(Morpholine-4-carbonyl)-amino]-2-phenyl-acrylic acid methyl ester 

Downstream Products

• 1188274-62-5 methyl (E)-2-phenyl-3-(p-toluenesulfonyloxy)prop-2-enoate 
• 1188274-63-6 methyl (Z)-2-phenyl-3-(p-toluenesulfonyloxy)prop-2-enoate 

Relevant academic research and scientific papers

General, Robust, and stereocomplementary preparation of α,β-disubstituted α,β-unsaturated esters

An (E)- and (Z)-stereocomplementary preparative method for α,β-disubstituted α,β-unsaturated esters Is performed via three general and robust reaction sequences: (i) TI-Claisen condensation (formylation) of esters to give α-formyl esters (12 examples, 60-99%), (II) (E)- and (Z)-stereocomplementary enol ρ-toluenesulfonylation (tosylation) using TsCI-N-methylimidazole (NMI)-Et3N and LiOH (24 examples, 82-99%), and (iii) stereoretentive Suzuki-Miyaura cross-coupling (18 examples, 64-96%).

The Vilsmeier-Haack Reaction of Isoxazolin-5-ones. Synthesis and Reactivity of 2-(Dialkylamino)-1,3-oxazin-6-ones

The Vilsmeier-Haack reaction on isoxazolin-5-ones gives 2-(dialkylamino)-1,3-oxazin-6-ones, and a reaction path is proposed depending on substitution pattern of the isoxazolin-5-ones studied.A thermal equilibrium between the oxazinones, imino ketenes, and vinyl isocyanates is hypothesized to explain most of the chemical reactivity of the 2-(dialkylamino)-1,3-oxazin-6-ones.