646055-63-2

Basic information

• Product Name: 7-Boc-1,7-diaza-spiro[4.4]nonane
• Synonyms: 7-Boc-1,7-diaza-spiro[4.4]nonane;1,7-DIAZA-SPIRO[4.4]NONANE-7-CARBOXYLIC ACID TERT-BUTYL ESTER;TERT-BUTYL 1,7-DIAZASPIRO[4.4]NONANE-7-CARBOXYLATE;1,1-Dimethylethyl 1,7-diazaspiro[4.4]nonane-7-carboxylate;tert-Butyl 2,6-diazaspiro[4.4]nonane-2-carboxylate;1,7-Diazaspiro[4.4]nonane-7-carboxylic acid, 1,1-diMethylethyl ester;1,7-Diaza-spiro[4.4]nonane-7-carboxylic acid t-butyl ester;1,7-Diazaspiro[4.4]nonane-7-carboxylic acid tert-butyl ester - D5982
• CAS NO: 646055-63-2
• Molecular Formula: C12H22N2O2
• Molecular Weight: 226.32
• Mol File: 646055-63-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 319.425°C at 760 mmHg
• Flash Point: 146.983°C
• Appearance: /
• Density: 1.089g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: 2-8°C(protect from light)
• PKA: 10.72±0.20(Predicted)
• CAS DataBase Reference: 7-Boc-1,7-diaza-spiro[4.4]nonane(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Boc-1,7-diaza-spiro[4.4]nonane(646055-63-2)
• EPA Substance Registry System: 7-Boc-1,7-diaza-spiro[4.4]nonane(646055-63-2)

Safety Data

• Hazardous Substances Data: 646055-63-2(Hazardous Substances Data)

Usage

General Description

7-Boc-1,7-diaza-spiro[4.4]nonane is a chemical compound with a spirocyclic structure that contains a 1,7-diaza ring system. It is often used as a key building block in the synthesis of pharmaceuticals and other complex organic molecules, due to its ability to act as a versatile chiral auxiliary. The compound features a Boc (tert-butoxycarbonyl) protecting group, which helps to enhance its stability and reactivity. This protecting group can be removed under mild conditions, making it a valuable tool in organic synthesis. Additionally, the spirocyclic structure of 7-Boc-1,7-diaza-spiro[4.4]nonane contributes to its unique stereochemical properties, making it a useful component in the preparation of stereoselective compounds. Overall, this compound is crucial in the field of organic chemistry for its role in the synthesis of complex and biologically active molecules.

InChI:InChI=1/C12H22N2O2/c1-11(2,3)16-10(15)14-8-6-12(9-14)5-4-7-13-12/h13H,4-9H2,1-3H3

Upstream product

• 646055-62-1 tert-butyl 6-benzyl-2,6-diazaspiro [4.4]nonane-2-carboxylate 
• 1510865-62-9 tert-butyl 3-(2-tosylhydrazono)-pyrrolidine-1-carboxylate 

Downstream Products

• 1158749-77-9 1-methyl-1,7-diazaspiro[4,4]nonane 

Relevant articles and documents

Construction of NH-Unprotected Spiropyrrolidines and Spiroisoindolines by [4+1] Cyclizations of γ-Azidoboronic Acids with Cyclic N-Sulfonylhydrazones

The reactions of N-sulfonylhydrazones derived from cyclic ketones with γ-azidopropylboronic acid and 2-(azidomethyl)phenylboronic acid give rise to spirocyclic pyrrolidines and spiroisoindolines, respectively. The reactions proceed without the need of any transition-metal catalyst through a domino process that comprises the formation of a Csp3-C and a Csp3-N bond of the former hydrazonic carbon. The scope of the reaction has been explored by the preparation of over 50 examples of NH-unprotected spirocyclic derivatives. Importantly, this methodology could be applied for the preparation of alkaloid steroids from steroid N-tosylhydrazones.

THE USE OF N-ARYL DIAZASPIRACYCLIC COMPOUNDS IN THE TREATMENT OF ADDICTION

Compounds, compositions and methods for treating drug addiction, nicotine addiction, and/or obesity are disclosed. The compounds are N-aryl diazaspirocyclic compounds, bridged analogs of N-heteraryl diazaspirocyclic compounds, or prodrugs or metabolites of these compounds. The aryl group can be a five- or six-membered heterocyclic ring (heteroaryl). The compounds are effective at inhibiting dopamine production and/or secretion, and accordingly are effective at inhibiting the physiological "reward" process that is associated with ingestion of nicotine and/or illicit drugs. The compounds and compositions can be administered in effective amounts to inhibit dopamine release, wihout resulting in appreciable adverse side effects (e.g., side effects such as significant increases in blood pressure and heart rate, significant negative effects upon the gastro-intestinal tract, and significant effects upon skeletal muscle).