6461-83-2Relevant academic research and scientific papers
Efficient reduction of esters to aldehydes through iridium-catalyzed hydrosilylation
Cheng, Chen,Brookhart, Maurice
supporting information, p. 9422 - 9424 (2012/10/30)
Trumping DIBALH: A new method for reduction of esters to aldehydes through silyl acetal intermediates involves a single-step hydrosilylation catalyzed by a readily available iridium complex, [{Ir(coe)2Cl}2] (see scheme; coe=cyclooctene). The low catalyst loading, mild reaction conditions, high conversions, and broad substrate scope make this method a superior alternative to ester reduction using DIBALH.
