64614-53-5 Usage
Chemical structure
The compound consists of a piperazine ring with a chlorine-substituted pyridine and a sulfonyl group attached to it, and a methyl group attached to the piperazine ring.
Pharmaceutical research and development
It is commonly used in pharmaceutical research and development due to its ability to interact with biological targets.
Synthesis of potential drug candidates
The compound is used in the synthesis of potential drug candidates.
Interaction with biological targets
The compound has the ability to interact with biological targets, which makes it useful in the development of new drugs.
Pharmacological properties
The compound may exhibit various pharmacological properties, which can be useful in the treatment of various diseases and conditions.
Modulation of biological processes
The compound may be involved in the modulation of biological processes, which can be useful in the development of new therapies.
Specific properties and applications
The specific properties and applications of this chemical may vary depending on the context and the specific research or industrial use case.
Molecular weight
The molecular weight of the compound is approximately 281.76 g/mol.
Solubility
The compound is likely to be soluble in polar solvents such as water and methanol, but its solubility in nonpolar solvents such as hexane or chloroform may be limited.
Stability
The stability of the compound may depend on factors such as temperature, pH, and exposure to light or air.
Safety and handling
As with any chemical compound, appropriate safety measures should be taken when handling and using 1-(6-chloro-pyridine-3-sulfonyl)-4-methyl-piperazine, including the use of personal protective equipment and proper disposal methods.
Check Digit Verification of cas no
The CAS Registry Mumber 64614-53-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,6,1 and 4 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 64614-53:
(7*6)+(6*4)+(5*6)+(4*1)+(3*4)+(2*5)+(1*3)=125
125 % 10 = 5
So 64614-53-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H14ClN3O2S/c1-13-4-6-14(7-5-13)17(15,16)9-2-3-10(11)12-8-9/h2-3,8H,4-7H2,1H3
64614-53-5Relevant academic research and scientific papers
Inhibition of cancer cell invasion by new ((3,4-dihydroxy benzylidene)hydrazinyl)pyridine-3-sulfonamide analogs
Kang, Seong-Mook,Nam, Ky-Youb,Jung, Seung-Youn,Song, Kyung-Hee,Kho, Seongho,No, Kyoung Tai,Choi, Hyun Kyung,Song, Jie-Young
, p. 1322 - 1328 (2016/02/23)
Rab GTPases regulate various types of intracellular membrane trafficking in all eukaryotes. Since Rab27a and its multiple effectors are involved in exocytosis of lysosome-related organelles and play a major role in malignancy, compounds targeting Rab27a could be likely used to inhibit invasive growth and tumor metastasis. Thus, we designed and synthesized several compounds based on the previously reported Rab27a-targeting synthetic compounds identified by virtual screening, and investigated their anti-metastatic effects in MDA-MB231 and A375 cells. Among the synthesized compounds, (E)-N-(3-chlorophenyl)-6-(2-(3,4-dihydroxy benzylidene)hydrazinyl)pyridine-3-sulfonamide (3d) and (E)-N-benzyl-6-(2-(3,4-dihydroxy benzylidene)hydrazinyl)-N-methylpyridine-3-sulfonamide (3f) significantly inhibited the invasiveness of both tumor cell lines. Compounds 3d and 3f also decreased the levels of signature extracellular matrix marker proteins (fibronectin, collagen, and α-smooth muscle actin) and representative mesenchymal cell markers (N-cadherin and vimentin). Taken together, our results suggest that novel sulfonamide analogs have anti-metastatic activity in breast and melanoma cancer cell lines and may be used as therapeutic agents to treat malignant cancer.
