64618-76-4

Basic information

• Product Name: 4-(3-methoxy-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-piperidine
• CAS NO: 64618-76-4
• Molecular Weight: 317.431
• Mol File: 64618-76-4.mol

Chemical Properties

• CAS DataBase Reference: 4-(3-methoxy-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-methoxy-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-piperidine(64618-76-4)
• EPA Substance Registry System: 4-(3-methoxy-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-piperidine(64618-76-4)

Safety Data

• Hazardous Substances Data: 64618-76-4(Hazardous Substances Data)

Upstream product

• 5570-77-4 4-chloro-1-methylpiperidine 
• 22725-38-8 3-methoxy-5H-dibenzo[a,d]cyclohepten-5-one 
• 63463-35-4 4-(3-iodo-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-piperidine 
• 12775-96-1 copper 

Relevant articles and documents

Development of Novel Inhibitors for Histone Methyltransferase SET7/9 based on Cyproheptadine

The histone methyltransferase SET7/9 methylates not only histone but also non-histone proteins as substrates, and therefore, SET7/9 inhibitors are considered candidates for the treatment of diseases. Previously, our group identified cyproheptadine, used clinically as a serotonin receptor antagonist and histamine receptor (H1) antagonist, as a novel scaffold of the SET7/9 inhibitor. In this work, we focused on dibenzosuberene as a substructure of cyproheptadine and synthesized derivatives with various functional groups. Among them, the compound bearing a 2-hydroxy group showed the most potent activity. On the other hand, a 3-hydroxy group or another hydrophilic functional group such as acetamide decreased the activity. Structural analysis clarified a rationale for the improved potency only by tightly restricted location and type of the hydrophilic group. In addition, a SET7/9 loop, which was only partially visible in the complex with cyproheptadine, became more clearly visible in the complex with 2-hydroxycyproheptadine. These results are expected to be helpful for further structure-based development of SET7/9 inhibitors.

3-Lower alkoxycyproheptadines as serotonin inhibitors

The levorotatory enantiomers of 3-loweralkoxy-cyproheptadines are potent antiserotonin agents with a lower order of antihistaminic activity and substantially free of any anticholinergic activity. They are prepared by treatment of the levorotatory enantiomer of 3-iodocyproheptadine with an alkali metal lower alkoxide in the presence of copper powder.