64622-21-5 Usage
Uses
Used in Pharmaceutical Research:
Ibuprofen Related Compound (2,3-Dihydroxypropyl 2-(4-Isobutylphenyl)Propanoate) is used as a research chemical for the investigation of unknown impurities in Ibuprofen soft capsules. This application is crucial for ensuring the quality, safety, and efficacy of Ibuprofen-based pharmaceutical products, as well as for identifying and mitigating potential risks associated with impurities.
Used in Drug Development:
In the drug development industry, Ibuprofen Related Compound (2,3-Dihydroxypropyl 2-(4-Isobutylphenyl)Propanoate) serves as a valuable tool for studying the structure-activity relationship (SAR) of Ibuprofen and its analogs. This information can be used to design and optimize new drugs with improved therapeutic properties, such as enhanced anti-inflammatory effects, reduced side effects, or targeted delivery to specific tissues or organs.
Used in Quality Control:
Ibuprofen Related Compound (2,3-Dihydroxypropyl 2-(4-Isobutylphenyl)Propanoate) is also utilized in quality control processes for Ibuprofen-containing products. It can be employed as a reference standard or an internal standard in analytical techniques such as high-performance liquid chromatography (HPLC), gas chromatography (GC), or mass spectrometry (MS) to accurately quantify and characterize Ibuprofen and its related compounds in pharmaceutical formulations.
Check Digit Verification of cas no
The CAS Registry Mumber 64622-21-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,6,2 and 2 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 64622-21:
(7*6)+(6*4)+(5*6)+(4*2)+(3*2)+(2*2)+(1*1)=115
115 % 10 = 5
So 64622-21-5 is a valid CAS Registry Number.
64622-21-5Relevant academic research and scientific papers
Ravelo, Marianela,Esteban, Jesús,Ladero, Miguel,García-Ochoa, Félix
, p. 69658 - 69669 (2016)
The enzymatic esterification of glycerol and ibuprofen in different organic media to obtain a monoester of ibuprofen was studied in an open and close system, selecting an adequate kinetic model in both cases. The solubility of ibuprofen was tested in various solvents, leading to the selection of toluene as the most appropriate organic medium. Preliminary runs led to fixing the concentration of lipase CALB-L at 2 g L-1, stirring speed at 720 rpm, a water content of 6% v/v and a glycerol to toluene volume ratio of 20/5. Kinetic runs were performed at several ibuprofen initial concentrations (20 to 100 g L-1) and temperatures (50 to 80 °C). Two systems were defined, one of which contemplated continuous removal of water with toluene. Considering kinetic and thermodynamic data, several kinetic models were proposed and fitted to all available data making use of physical and statistical criteria to select the best ones. In the first system, the chosen model was an irreversible hyperbolic model, whereas in the other system, the selected model was a Michaelis-Menten-based reversible model of pseudo-first order with respect to the concentration of ibuprofen and the monoester.
