64630-29-1

Basic information

• Product Name: Benzene, (2-isocyanoethenyl)-, (Z)-
• CAS NO: 64630-29-1
• Molecular Formula: C9H7N
• Molecular Weight: 129.161
• Mol File: 64630-29-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzene, (2-isocyanoethenyl)-, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, (2-isocyanoethenyl)-, (Z)-(64630-29-1)
• EPA Substance Registry System: Benzene, (2-isocyanoethenyl)-, (Z)-(64630-29-1)

Safety Data

• Hazardous Substances Data: 64630-29-1(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 99128-10-6 (isocyanomethyl)triphenylphosphonium chloride 
• 41003-94-5 diethyl isocyanomethylphosphonate 

Relevant articles and documents

Synthesis of Vinyl Isocyanides and Development of a Convertible Isonitrile

The reaction of isocyanomethylenetriphenylphosphorane, generated in situ from the corresponding phosphonium salt, with a diverse set of aldehydes afforded vinyl isocyanides in good to high yields. Excellent E-selectivity was observed for aliphatic aldehydes and 2,6-disubstituted aromatic aldehydes, whereas Z-olefins were formed predominantly with ortho-substituted aryl aldehydes. (Z)-1-Bromo-2-(2-isocyanovinyl)benzene (5l) was found to be a truly universal isonitrile since, after Ugi reaction, the resulting secondary amide unit (RNHCO-) is convertible under both acidic and basic conditions. The application of 5l in the synthesis of polyheterocycles is also illustrated.