6464-98-8

Basic information

• Product Name: methyl (3-aminophenyl)carbamate(SALTDATA: HCl)
• Synonyms: methyl (3-aminophenyl)carbamate(SALTDATA: HCl);methyl 3-aminophenylcarbamate
• CAS NO: 6464-98-8
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.1772
• Mol File: 6464-98-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: methyl (3-aminophenyl)carbamate(SALTDATA: HCl)(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (3-aminophenyl)carbamate(SALTDATA: HCl)(6464-98-8)
• EPA Substance Registry System: methyl (3-aminophenyl)carbamate(SALTDATA: HCl)(6464-98-8)

Safety Data

• Hazardous Substances Data: 6464-98-8(Hazardous Substances Data)

Upstream product

• 108-45-2 m-phenylenediamine 
• 79-22-1 methyl chloroformate 
• 99-65-0 meta-dinitrobenzene 
• 616-38-6 carbonic acid dimethyl ester 
• 2189-61-9 (3-nitro-phenyl)-carbamic acid methyl ester 
• 4366-93-2 potassium carbamate 
• 99-09-2 3-nitro-aniline 

Downstream Products

• 69449-25-8 (3-Ethylsulfanylthiocarbonylamino-phenyl)-carbamic acid methyl ester 
• 69449-55-4 (3-Phenylsulfanylthiocarbonylamino-phenyl)-carbamic acid methyl ester 
• 55508-55-9 methyl m-(3-t-butylureido)carbanilate 
• 1308255-68-6 methyl 5-amino-2-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)phenylcarbamate 
• 1308256-78-1 methyl 2-(chlorosulfonyl)-5-(2,2,2-trifluoroacetamido)phenyl carbamate 
• 1308256-77-0 methyl 3-(2,2,2-trifluoroacetamido)phenylcarbamate 
• 35202-61-0 methyl m-(2-methylvaleramido)carbanilate 
• 69449-41-8 [3-(4-Chloro-phenoxythiocarbonylamino)-phenyl]-carbamic acid methyl ester 
• 69449-54-3 (3-Phenoxythiocarbonylamino-phenyl)-carbamic acid methyl ester 
• 69449-35-0 (3-Methylsulfanylcarbonylamino-phenyl)-carbamic acid methyl ester 
• 69449-37-2 (3-Methylsulfanylthiocarbonylamino-phenyl)-carbamic acid methyl ester 
• 69568-29-2 (3-Benzylsulfanylcarbonylamino-phenyl)-carbamic acid methyl ester 
• 69449-28-1 (3-Phenylsulfanylcarbonylamino-phenyl)-carbamic acid methyl ester 
• 69450-16-4 N-(3-Isothiocyanatophenyl)-O-methylcarbamat 

Relevant articles and documents

Discovery of HN37 as a Potent and Chemically Stable Antiepileptic Drug Candidate

We previously reported that P-retigabine (P-RTG), a retigabine (RTG) analogue bearing a propargyl group at the nitrogen atom in the linker of RTG, displayed moderate anticonvulsant efficacy. Recently, our further efforts led to the discovery of HN37 (pynegabine), which demonstrated satisfactory chemical stability upon deleting the ortho liable -NH2 group and installing two adjacent methyl groups to the carbamate motif. HN37 exhibited enhanced activation potency toward neuronal Kv7 channels and high in vivo efficacy in a range of pre-clinical seizure models, including the maximal electroshock test and a 6 Hz model of pharmacoresistant limbic seizures. With its improved chemical stability, strong efficacy, and better safety margin, HN37 has progressed to clinical trial in China for epilepsy treatment.

ONE-POT PRODUCTION OF CARBAMATES USING SOLID CATALYSTS

The invention relates to the production of carbamates in a single reactor (one-pot) using solid catalysts, involving the reaction between at least one nitro compound, an organic carbonate of formula (OR)(OR′)C═O, a gas selected from hydrogen gas and a mixture of gases containing hydrogen and hydrogen precursor compounds, and a catalyst that has at least one metallic oxide and can also contain an element of groups 8, 9, 10 and 11 of the periodical table. The carbonates obtained can be transformed into their corresponding isocyanates.

Meta-bifunctional benzenes and herbicidal compositions

Meta-bifunctional of the general formula EQU1 wherein A is selected from the groups EQU2 These compounds possess herbicidal activity.