646522-36-3Relevant academic research and scientific papers
A concise synthesis of pyrimidinophanes from 6-aryl-5-cyano-2-thiouracil
Upadhyay,Agarwal, Nidhi,Goel, Atul,Ram, Vishnu Ji.
, p. 380 - 382 (2007/10/03)
A convenient synthesis of 2,3- and 2,4-pyrimidinophanes (3,5,6) has been described from 6-aryl-5-cyano-2-thiouracils (1a-c). A reaction of 2-thiouracil with dibromomethane produced 2a-c, which on further interaction with dihaloalkane under basic condition produced 2,3-pyrimidinophanes (3a,b). Halogenation of 2a,c with POCl3 led to yield respective chloropyrimidines (4a,b), which on further reaction with diaminoalkane and 1,4-phenylenediamine separately yielded 2,4-pyrimidinophanes (5a-d and 6a,b).
