64671-18-7

Usage

Chemical Properties

Off-White Solid

Uses

Intermediate in the preparation of Risperidone derivatives.

Upstream product

• 25503-90-6 1-acetyl-piperidine-4-carboxylic acid 
• 59084-16-1 1-acetylpiperidine-4-carbonyl chloride 
• 151-10-0 1,3-Dimethoxybenzene 

Downstream Products

• 84162-88-9 4-(2-hydroxy-4-methoxybenzoyl)piperidine hydrochloride 
• 84162-91-4 phenylmethyl 4-(2-hydroxy-4-methoxybenzoyl)-1-piperidinecarboxylate 
• 64671-19-8 4-(2-hydroxy-4-methoxybenzoyl)piperidine 
• 84163-61-1 1-acetyl-4-(2-hydroxy-4-methoxy-benzoyl)piperidine o-acetyl oxime 

Relevant academic research and scientific papers

Synthesis and Neuroleptic Activity of 3-(1-Substituted-4-piperidinyl)-1,2-benzisoxazoles

The synthesis of a series of 3-(1-substituted-4-piperidinyl)-1,2-benzisoxazoles is described.The neuroleptic activity of the series was evaluated by utilizing the climbing mice assay and inhibition of spiroperidol binding.Structure-activity relationships were studied by variation of the substituent on the benzisoxazole ring with concomitant variation of four different 1-piperidinyl substituents.Maximum neuroleptic activity was realized when there was a 6-fluoro substituent on the benzisoxazole ring.The 1-piperidinyl substituent appeared less significant, although in most cases, the (1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)propyl group imparted maximum potency.The most potent compound in both assays was 6-fluoro-3--4-piperidinyl>-1,2-benzisoxazole (11b).