64675-73-6Relevant academic research and scientific papers
Synthetic studies towards 1,5-benzodiazocines
Pettersson, Birgitta,Bergman, Jan,Svensson, Per H.
, p. 2647 - 2654 (2013/03/28)
Anthranilonitrile reacted with phenylmagnesium bromide to yield a dianion, which when heated (～120 °C) yielded the condensation product 2-(2-aminophenyl)-2,4-diphenyl-1,2-dihydroquinazoline 8. This heterocycle, when treated with palladium acetate, was converted into 6,12-diphenyldibenzo[b,f][1, 5]diazocine 9. Methylmagnesium bromide and anthranilonitrile, under similar conditions directly gave a nitrogen-bridged diazocine, whose structure was determined by X-ray crystallography and also proven to be an analogue of Tro?ger's base. Acid-induced condensation of 2-amino-3-methoxybenzaldehyde gave the trimeric product 45 rather than a dibenzo[b,f][1,5]diazocine.
Synthesis of polysubstituted analogues of the 4-methyl-2-phenylquinoline
Al-Qahtani,Al-Turki,Khan,Mousa,Alkhathlan
, p. 6055 - 6058 (2013/07/26)
A simple and convenient synthetic method for the direct synthesis of a series of polysubstituted analogues of the putative antifungal agent 4-methyl-2-phenylquinoline, a mimic of the natural bioactive 4-methoxy-2-phenylquinoline is reported.
