64681-98-7

Upstream product

• 100-52-7 benzaldehyde 
• 105-45-3 acetoacetic acid methyl ester 
• 15768-07-7 methyl 2-benzylidene-3-oxobutanoate 

Downstream Products

• 142592-22-1 1,5-dimethoxycarbonyl-2-methyl-6-phenyl-4-piperidino-1,3-cyclohexadiene 
• 24904-04-9 4,6-dimethoxycarbonyl-3-methyl-5-phenyl-2-cyclohexenone 
• 142592-01-6 1,5-dimethoxycarbonyl-2-methyl-4-morpholino-6-phenyl-1,3-cyclohexadiene 
• 94445-20-2 2,4-dimethoxycarbonyl-5-methyl-3-phenylcyclohexen-1-one 
• 1176846-02-8 C₂₄H₂₇NO₅ 
• 1013755-52-6 C₂₅H₂₉NO₅ 
• 1013986-40-7 C₂₇H₃₃NO₇ 
• 936079-25-3 dimethyl 4-[2-(1H-indol-3-yl)ethylamino]-6-methyl-2-phenylcyclohexa-3,5-diene-1,3-dicarboxylate 
• 1020373-69-6 5-methoxycarbonyl-6-hydroxy-6-methyl-4-phenyl-4,5,6,7-tetrahydro-3-hydroxy-1H-indazole 
• 94445-22-4 2,4-dimethoxycarbonyl-5-methyl-3-phenylcyclohexan-1-ol 

Relevant academic research and scientific papers

A mild and convenient one-pot synthesis of 4-aryl-n-oh-hantzsch esters

A general methodology to prepare a series of 4-Aryl-N-OH Hantzsch esters was developed. The key factor is to control the first-step of Michael addition at 0 °C. The method was practical to produce symmetrical and unsymmetric N-OH-Hantzsch esters in moderate yield. This class of compounds might have use in medicinal and material science.

An efficient regioselective synthesis of functionalized biphenyls via sequential reactions of aromatic aldehydes and β-keto esters or ketones

Knoevenagel/Michael/Aldol reactions of aromatic aldehydes and β-keto esters/ketones in a sequential manner yielded intermediate cyclohexanones in good yields. The latter, on oxidative aromatization with iodine, afforded functionalized biphenyls with at le

A facile synthesis of 4-aryl-5-alkoxycarbonyl-6-hydroxy-6-methyl-4,5,6,7-tetrahydro-3-hydroxy-2-(pyridin-2-yl)-indazoles and their nmr characterizations

A series of N-pyridinyl tetrahydroindazoles have been synthesized by a convenient and regioseletive method by taking cyclic 2-ketoesters as scaffolds. An optimum reaction condition was achieved by monitoring the reaction in different reaction c

Reaction of dialkyl 2-aryl-4-hydroxy-4-methyl-6-oxocyclohexane-1,3- dicarboxylates with aliphatic amines

Benzylamine, phenethylamine, and homoveratrylamine reacted with dialkyl 2-aryl-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylates at the endocyclic carbonyl group with conservation of the enolic hydroxy group to give dialkyl 4-alkylamino-2-aryl-6-hydroxy-6-methylcyclohex-3-ene-1,3-dicarboxylates. The reaction of dimethyl 4-hydroxy-4-methyl-6-oxo-2-phenylcyclohexane-1,3- dicarboxylate with tryptamine was accompanied by dehydration with formation of dimethyl 4-[2-(1H-indol-3-yl)ethylamino]-6-methyl-2-phenylcyclohexa-3,5-diene-1, 3-dicarboxylate, presumably due to basic properties of the indole nitrogen atom.

Synthesis and structures of 6-aryl-1,5-dimethoxycarbonyl-2-methyl-4-morpholino-1,3-cyclohexadienes and related compounds

Reaction of benzaldehyde (1a) with methyl acetoacetate (2) in the presence of morpholine (or piperidine) and AcOH in refluxing C6H6 yielded a new condensation product, 1,5-dimethoxycarbonyl-2-methyl-4-morpholino (or piperidino)-6-phe