64682-83-3

Upstream product

• 64682-83-3 (RS)-2-phenoxy-3-phenylpropionic acid 
• 110510-48-0 (R)-3-(3,4-Dimethoxy-phenyl)-2-methyl-2-((3R,4S)-2-oxo-3-phenoxy-4-phenyl-azetidin-1-yl)-propionic acid tert-butyl ester 
• 110510-47-9 (R)-2-Methyl-2-((3R,4S)-2-oxo-3-phenoxy-4-phenyl-azetidin-1-yl)-butyric acid tert-butyl ester 
• 102209-06-3 1-<(S)-1-(t-butoxycarbonyl)ethyl>-(3R,4S)-3-phenoxy-4-phenylazetidin-2-one 

Relevant academic research and scientific papers

HPLC separation of 2-aryloxycarboxylic acid enantiomers on chiral stationary phases

The possibility for separating enantiomers of a number of practically significant 2-aryloxycarboxylic acids was studied by normal- and reversed-phase HPLC on popular chiral stationary phases. The best separation parameters were achieved on the chiral phases with the polysaccharide base Chiralcel OD-H and Chiralpack AD under the normal-phase HPLC conditions. The (S)- and (R)-enantiomers of 2-(1-naphthyloxy)- and 2-(2-iodophenoxy)propionic acids with enantiomeric excess ee >99% were isolated using preparative chiral HPLC.

Asymmetric hydrogenation method of alpha-oxo-alpha, beta-unsaturated carboxylic acid

The invention relates to an asymmetric hydrogenation method of alpha-oxo-alpha, beta-unsaturated carboxylic acid. A metal complex containing ChenPhos chiral ligand is a catalyst high in conversion efficiency, and particularly, the catalyst can be used for