64686-48-2Relevant academic research and scientific papers
An Enyne Cope Rearrangement Enables Polycycloalkane Synthesis from Readily Available Starting Materials
Scott, Sarah K.,Grenning, Alexander J.
, p. 8125 - 8129 (2017)
Cyclohexanone-derived Knoevenagel adducts (cyclohexylidenemalononitriles) and two different propargyl electrophiles serve as carbon sources for assembling diverse 6/7/5 tricycloalkanes, a common terpenoid framework. The sequence involves three unique reac
Methods and compositions for terpenoid tricycloalkane synthesis
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Page/Page column 49; 50; 93; 94; 101; 102, (2019/05/26)
In one aspect, the disclosure relates to methods for preparation of intermediates useful for the preparation of terpenoid cores. In a further aspect, the disclosed methods pertain to the preparation of compounds comprising a terpenoid core or scaffold, su
Controlling, Understanding, and Redirecting the Thermal Rearrangement of 3,3-Dicyano-1,5-enynes
Scott, Sarah K.,Sanders, Jacob N.,White, Katherine E.,Yu, Roland A.,Houk,Grenning, Alexander J.
supporting information, p. 16134 - 16139 (2018/11/27)
The thermal [3,3] rearrangement of 3,3-dicyano-1,5-enynes to γ-allenyl alkylidenemalononitriles (the "enyne Cope rearrangement") has largely eluded synthetic value as the desired products, too, are thermally reactive and ultimately yield 6π electrocycliza
