64686-60-8Relevant academic research and scientific papers
Triflic anhydride-mediated synthesis of oxazoles
Thalhammer, Armin,Mecinovi?, Jasmin,Schofield, Christopher J.
supporting information; experimental part, p. 1045 - 1047 (2009/05/31)
N-Acyl amino acid esters undergo triflic anhydride-mediated cyclodehydration to form oxazoles and bisoxazoles in a simple one-pot transformation.
A versatile cyclodehydration reaction for the synthesis of isoquinoline and β-carboline derivatives
Movassaghi, Mohammad,Hill, Matthew D.
supporting information; experimental part, p. 3485 - 3488 (2009/05/07)
(Chemical Equation Presented) The direct conversion of various amides to isoquinoline and β-carboline derivatives via mild electrophilic amide activation, with trifluoromethanesulfonic anhydride in the presence of 2-chloropyridine, is described. Low-temperature amide activation followed by cyclodehydration upon warming provides the desired products with short overall reaction times. The successful use of nonactivated and halogenated phenethylene derived amides, N-vinyl amides, and optically active substrates is noteworthy.
