64686-82-4

Usage

InChI:InChI=1/C11H11N3OS2/c12-9-8(10(13)15)17-11(16)14(9)6-7-4-2-1-3-5-7/h1-5H,6,12H2,(H2,13,15)

Upstream product

• 622-78-6 Benzyl isothiocyanate 
• 107-91-5 cyanoacetic acid amide 

Downstream Products

• 81402-90-6 4-Amino-3-benzyl-2-dicyanomethylene-2,3-dihydro-thiazole-5-carboxylic acid amide 
• 172749-79-0 4-Benzoyl-3-benzyl-5-phenylthiazolo<4,5-d>pyrimidin-7(6H)-one-2(3H)-thione 
• 172749-78-9 3-Benzyl-5-phenyl-7-ethoxythiazolo<4,5-d>pyrimidin-2(3H)-thione 
• 172749-83-6 3-Benzyl-5-phenyl-7-methoxythiazolo<4,5-d>pyrimidin-2(3H)-thione 
• 64686-95-9 3-Benzylthiazolo<4,5-d>pyrimidin-7(6H)-one-2(3H)-thione 
• 172749-82-5 3-Benzyl-5-phenylthiazolo<4,5-d>pyrimidin-7(6H)-one-2(3H)-thione 
• 81403-02-3 3-Amino-5-benzylamino-thiophene-2,4-dicarbonitrile 

Relevant academic research and scientific papers

Synthesis of new 3-benzyl-5-phenyl-7-alkylaminothiazolo [4,5-d]pyrimidine-2(3H)-thiones

This paper describes the preparation of title compounds starting from 3-benzyl-4-amino-5-carboxyamidothiazole-2(3H)-thione, which, by heating with alkyl orthobenzoates, was converted into 3-benzyl-5-phenyl-7-alkoxy-thiazolo[4,5-d]pyrimidines. The treatment of these compounds with hydrobromic acid in acetic acid gave 3-benzyl-5-phenyl-7-oxo-thiazolo[4,5-d]pyrimidine-2(3H)-thione which, by reaction with phosphorus oxychloride and subsequent substitution of the halogen with amines, gave the corresponding title compounds.

Synthesis and pharmacological properties of some 4-amino-5-substituted thiazole-2(3H)-thiones and thiazolo(4,5 d)pyrimidin-7(6H) one-2(3H)-thiones

4-Amino-5-substituted thiazole-2(3h)-thiones and thiazolo(4,5-d)-pyrimdin-7(6H) -one-2(3H)-thiones have been synthesized and screened for antimicrobial and pharmacological activities. Significant analgesic, antiinflammatory, anticonvulsant and antimicrobi