64686-95-9Relevant academic research and scientific papers
Synthesis of new 3-benzyl-5-phenyl-7-alkylaminothiazolo [4,5-d]pyrimidine-2(3H)-thiones
Biagi,Giorgi,Livi,Scartoni
, p. 579 - 586 (2007/10/03)
This paper describes the preparation of title compounds starting from 3-benzyl-4-amino-5-carboxyamidothiazole-2(3H)-thione, which, by heating with alkyl orthobenzoates, was converted into 3-benzyl-5-phenyl-7-alkoxy-thiazolo[4,5-d]pyrimidines. The treatment of these compounds with hydrobromic acid in acetic acid gave 3-benzyl-5-phenyl-7-oxo-thiazolo[4,5-d]pyrimidine-2(3H)-thione which, by reaction with phosphorus oxychloride and subsequent substitution of the halogen with amines, gave the corresponding title compounds.
Synthesis and pharmacological properties of some 4-amino-5-substituted thiazole-2(3H)-thiones and thiazolo(4,5 d)pyrimidin-7(6H) one-2(3H)-thiones
Devani,Shishoo,Pathak,Parikh,Radhakrishnan,Padhya
, p. 1652 - 1655 (2007/10/09)
4-Amino-5-substituted thiazole-2(3h)-thiones and thiazolo(4,5-d)-pyrimdin-7(6H) -one-2(3H)-thiones have been synthesized and screened for antimicrobial and pharmacological activities. Significant analgesic, antiinflammatory, anticonvulsant and antimicrobi
