6469-49-4

Basic information

• Product Name: 3-ethyl-1-(4-fluoro-phenyl)-6-p-tolyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one
• CAS NO: 6469-49-4
• Molecular Weight: 349.408
• Mol File: 6469-49-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-ethyl-1-(4-fluoro-phenyl)-6-p-tolyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ethyl-1-(4-fluoro-phenyl)-6-p-tolyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one(6469-49-4)
• EPA Substance Registry System: 3-ethyl-1-(4-fluoro-phenyl)-6-p-tolyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one(6469-49-4)

Safety Data

• Hazardous Substances Data: 6469-49-4(Hazardous Substances Data)

Upstream product

• 6469-47-2 N-(4-methylphenyl)-6-aminohexan-3-one 
• 624-31-7 4-tolyl iodide 
• 3063-79-4 N-(4-methylphenyl)-2-pyrrolidinone 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 
• 162142-32-7 3-hydroxy-2-oxo-4-propionyl-1-(4-methylphenyl)-1,2,5,6-tetrahydropyridine 

Relevant articles and documents

7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as novel inhibitors of human eosinophil phosphodiesterase

High-throughput file screening against inhibition of human lung PDE4 led to the discovery of 3-ethyl-1-(4-fluorophenyl)-6-phenyl-7-oxo-4,5,6,7,- tetrahydro-1H-pyrazolo[3,4-c]pyridine (11) as a novel PDE4 inhibitor. Subsequent SAR development, using an eosinophil PDE assay, led to analogues up to 50-fold more potent than 11 with IC50 values of 0.03-1.6 μM. One such compound, CP-220,629 (22) (IC50 = 0.44 μM), was efficacious in the guinea pig aerosolized antigen induced airway obstruction assay (ED50 2.0 mg/kg, po) and demonstrated a significant reduction in eosinophil (55%), neutrophil (65%), and IL-1β (82%) responses to antigen challenge in atopic monkeys (10 mg/kg, po).