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3-ethyl-1-(4-fluoro-phenyl)-6-p-tolyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one is a complex organic compound with a molecular formula of C21H22FN3O. It features a pyrazolo[3,4-c]pyridin-7-one core structure, which is a heterocyclic ring system containing both nitrogen and oxygen atoms. The compound is characterized by the presence of a 4-fluoro-phenyl group, a p-tolyl group, and an ethyl group. The 4-fluoro-phenyl group introduces a fluorine atom at the para position of the phenyl ring, while the p-tolyl group adds a methyl group at the para position of another phenyl ring. The ethyl group is attached to the 3-position of the pyrazolo[3,4-c]pyridin-7-one core. 3-ethyl-1-(4-fluoro-phenyl)-6-p-tolyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one is a tetrahydro derivative, indicating that it contains four hydrogen atoms in a saturated ring structure. It is likely to be of interest in medicinal chemistry due to its potential as a precursor or intermediate in the synthesis of pharmaceuticals, given its complex structure and the presence of functional groups that can interact with biological targets.

6469-49-4

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6469-49-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6469-49-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,4,6 and 9 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 6469-49:
(6*6)+(5*4)+(4*6)+(3*9)+(2*4)+(1*9)=124
124 % 10 = 4
So 6469-49-4 is a valid CAS Registry Number.

6469-49-4Downstream Products

6469-49-4Relevant academic research and scientific papers

7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as novel inhibitors of human eosinophil phosphodiesterase

Duplantier, Allen J.,Andresen, Catharine J.,Cheng, John B.,Cohan, Victoria L.,Decker, Christian,DiCapua, Frank M.,Kraus, Kenneth G.,Johnson, Kerry L.,Turner, Claudia R.,UmLand, John P.,Watson, John W.,Wester, Ronald T.,Williams, Alison S.,Williams, John A.

, p. 2268 - 2277 (2007/10/03)

High-throughput file screening against inhibition of human lung PDE4 led to the discovery of 3-ethyl-1-(4-fluorophenyl)-6-phenyl-7-oxo-4,5,6,7,- tetrahydro-1H-pyrazolo[3,4-c]pyridine (11) as a novel PDE4 inhibitor. Subsequent SAR development, using an eosinophil PDE assay, led to analogues up to 50-fold more potent than 11 with IC50 values of 0.03-1.6 μM. One such compound, CP-220,629 (22) (IC50 = 0.44 μM), was efficacious in the guinea pig aerosolized antigen induced airway obstruction assay (ED50 2.0 mg/kg, po) and demonstrated a significant reduction in eosinophil (55%), neutrophil (65%), and IL-1β (82%) responses to antigen challenge in atopic monkeys (10 mg/kg, po).

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