3063-79-4

Basic information

• Product Name: 1-(4-METHYLPHENYL)-2-PYRROLIDINONE
• Synonyms: 1-(4-METHYLPHENYL)-2-PYRROLIDINONE;1-(4-METHYLPHENYL)-2-PYRROLIDINONE 99+%;1-(4-Methylphenyl)pyrrolidin-2-one;1-(p-Methylphenyl)pyrrolidine-2-one;2-pyrrolidinone, 1-(4-methylphenyl)-;1-(4-methylphenyl)-2-pyrrolidone;2-Pyrrolidinone, 1-p-tolyl-;1-(P-TOLYL)PYRROLIDIN-2-ONE
• CAS NO: 3063-79-4
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.23
• Mol File: 3063-79-4.mol
• Article Data: 36

Chemical Properties

• Melting Point: 86-88 °C
• Boiling Point: 306.53°C (rough estimate)
• Flash Point: 191 °C
• Appearance: Beige crystalline powder
• Density: 1.0582 (rough estimate)
• Vapor Pressure: 3.5E-06mmHg at 25°C
• Refractive Index: 1.5260 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.06±0.20(Predicted)
• CAS DataBase Reference: 1-(4-METHYLPHENYL)-2-PYRROLIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHYLPHENYL)-2-PYRROLIDINONE(3063-79-4)
• EPA Substance Registry System: 1-(4-METHYLPHENYL)-2-PYRROLIDINONE(3063-79-4)

Safety Data

• Safety Statements: 24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 3063-79-4(Hazardous Substances Data)

Usage

Chemical Properties

BEIGE CRYSTALLINE POWDER

InChI:InChI=1/C11H13NO/c1-9-4-6-10(7-5-9)12-8-2-3-11(12)13/h4-7H,2-3,8H2,1H3

Upstream product

• 96-48-0 4-butanolide 
• 106-49-0 p-toluidine 
• 2314-79-6 N-(p-tolyl)succinimide 
• 87962-88-7 4-p-toluidino-butyric acid 
• 616-45-5 2-pyrrolidinon 
• 624-31-7 4-tolyl iodide 
• 108-44-1 1-amino-3-methylbenzene 
• 356086-86-7 4-(p-tolylamino)butan-1-ol 
• 106-38-7 para-bromotoluene 
• 31053-03-9 N-(4-methylphenyl)piperidine 
• 2969-81-5 Ethyl 4-bromobutyrate 
• 54104-82-4 1-p-tolylpyrrolidine 
• 5720-05-8 4-methylphenylboronic acid 
• 615-37-2 ortho-methylphenyl iodide 

Downstream Products

• 58973-35-6 N-(4-methylphenyl)pyrrolidine-2-thione 
• 6469-47-2 N-(4-methylphenyl)-6-aminohexan-3-one 
• 162142-32-7 3-hydroxy-2-oxo-4-propionyl-1-(4-methylphenyl)-1,2,5,6-tetrahydropyridine 
• 6469-49-4 3-ethyl-1-(4-fluoro-phenyl)-6-p-tolyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one 
• 186667-93-6 diethyl [1-(4-methylphenyl)pyrrolidin-2-ylidene]malonate 
• 87962-88-7 4-p-toluidino-butyric acid 

Relevant articles and documents

Synthetic method of N - aryl substituted lactam compound

The invention discloses a method. NSynthesis method of - aryl substituted lactam compound, and synthesis method thereof is promoted by tertiary butyl hydroperoxide and-tert-butyl hydroperoxideNMulti-step series reaction synthesis - aryl substituted saturated cyclic amine compoundN- Aryl substituted lactam compounds are simple and convenient to operate. The method has the advantages of no transition metal catalysis, wide substrate application range and the like, and is suitable for industrial production.

Ruthenium-catalyzed synthesis of: N -substituted lactams by acceptorless dehydrogenative coupling of diols with primary amines

Herein, we report the first example of synthesis of N-substituted lactams via an acceptorless dehydrogenative coupling of diols with primary amines in one step, which was enabled by combining Ru3(CO)12 with a hybrid N-heterocyclic carbene-phosphine-phosphine ligand as the catalyst.

Selective synthesis of pyrrolidin-2-ones and 3-iodopyrroles: Via the ring contraction and deformylative functionalization of piperidine derivatives

In this paper, a selective synthesis of pyrrolidin-2-ones and 3-iodopyrroles via the cascade reactions of N-substituted piperidines is presented. Mechanistically, the formation of pyrrolidin-2-ones involves a domino process including the in situ formation of pyrrolidine-2-carbaldehyde followed by carboxylic acid formation, decarboxylation and ipso-oxidation. On the other hand, 3-iodopyrroles are believed to be formed via the initial generation of pyrrolidine-2-carbaldehyde followed by carboxylic acid formation, decarboxylation, dehydrogenation, iodination and aromatization. Interestingly, either pyrrolidin-2-ones or 3-iodopyrroles could be obtained selectively from the same substrates, and the selectivity was easily tuned by using a specific oxidant and additive.