64695-81-4

Usage

Uses

Used in Pharmaceutical Industry:
N-(2-Bromo-4,5-difluorophenyl)acetamide is used as a pharmaceutical intermediate for the development of new drugs. Its antiviral and antibacterial properties make it a promising candidate for the treatment of various infectious diseases.
Used in Research Applications:
In the field of research, N-(2-Bromo-4,5-difluorophenyl)acetamide is utilized as a chemical probe to study the mechanisms of action of various biological processes. Its potential use in the treatment of diseases allows researchers to explore its therapeutic effects and understand its mode of action.
Used in Antiviral and Antibacterial Agents:
N-(2-Bromo-4,5-difluorophenyl)acetamide is used as an antiviral and antibacterial agent due to its inherent properties. It can be further developed and optimized to target specific pathogens, potentially leading to the creation of new and effective treatments for viral and bacterial infections.
Used in Disease Treatment:
N-(2-Bromo-4,5-difluorophenyl)acetamide has been studied for its potential use in the treatment of various diseases. Its therapeutic effects are being investigated to determine its efficacy and safety in treating specific medical conditions, with the aim of developing new treatment options for patients.

InChI:InChI=1/C8H6BrF2NO/c1-4(13)12-8-3-7(11)6(10)2-5(8)9/h2-3H,1H3,(H,12,13)

Upstream product

• 64695-79-0 2-bromo-4,5-difluoro-aniline 
• 108-24-7 acetic anhydride 
• 458-11-7 3,4-difluoroacetanilide 
• 3863-11-4 3,4-difluoroaniline 

Downstream Products

• 80076-46-6 (+/-)-5,6-difluoro-2-methyl-1,2,3,4-tetrahydroquinoline 
• 131190-82-4 8-bromo-5,6-difluoro-2-methylquinoline 
• 170881-41-1 5,6-difluoro-2-methylbenzo[d]thiazole 

Relevant academic research and scientific papers

Synthesis and antileishmanial activity of fluorinated rhodacyanine analogues: The ‘fluorine-walk’ analysis

In a search for potent antileishmanial drug candidates, eighteen rhodacyanine analogues bearing fluorine or perfluoroalkyl substituents at various positions were synthesized. These compounds were tested for their inhibitory activities against Leishmania martiniquensis and L. orientalis. This ‘fluorine-walk’ analysis revealed that the introduction of fluorine atom at C-5, 6, 5′, or 6′ on the benzothiazole units led to significant enhancement of the activity, correlating with the less negative reduction potentials of the fluorinated analogues confirmed by the electrochemical study. On the other hand, [sbnd]CF3 and [sbnd]OCF3 groups were found to have detrimental effects, which agreed with the poor aqueous solubility predicted by the in silico ADMET analysis. In addition, some of the analogues including the difluorinated species showed exceptional potency against the promastigote and axenic amastigote stages (IC50 = 40–85 nM), with the activities surpassing both amphotericin B and miltefosine.

Synthesis, antibacterial activities, mode of action and acute toxicity studies of new oxazolidinone-fluoroquinolone hybrids

To combat bacterial resistance, a series of new oxazolidinone-fluoroquinolone hybrids have been synthesized and characterized. All synthetic hybrids were preliminarily evaluated for their in vitro antibacterial activities against 6 standard strains and 3 clinical isolates. The majority of hybrids displayed excellent activities against Gram-positive bacteria, but limited activities against Gram-negative bacteria. Hybrids OBP-4 and OBP-5 were found to be the most promising compounds. Further, in vitro antibacterial activities, mode of action and acute toxicity in mice of hybrids OBP-4 and OBP-5 were investigated. Hybrids OBP-4 and OBP-5 exhibited potent activities against Gram-positive bacteria, including drug-resistant strains. Correspondingly, studies on the mode of action of hybrids OBP-4 and OBP-5 indicated a strong inhibitory activity on protein synthesis by binding the active site of 50S subunit, but a weak inhibitory action on DNA synthesis. In addition, LD50 values of hybrids OBP-4 and OBP-5 in the acute oral toxicity were larger than 2000 mg/kg, suggesting a good safety profile.