64695-81-4

Basic information

• Product Name: N-(2-BROMO-4,5-DIFLUOROPHENYL)ACETAMIDE
• Synonyms: N-(2-BROMO-4,5-DIFLUOROPHENYL)ACETAMIDE;2'-Bromo-4',5'-difluoroacetanilide;N-(2-Bromo-4.5-difluorophenl)actamide
• CAS NO: 64695-81-4
• Molecular Formula: C₈H₆BrF₂NO
• Molecular Weight: 250.0401464
• Mol File: 64695-81-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 323.327 °C at 760 mmHg
• Flash Point: 149.343 °C
• Appearance: /
• Density: 1.7 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.39±0.70(Predicted)
• CAS DataBase Reference: N-(2-BROMO-4,5-DIFLUOROPHENYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-BROMO-4,5-DIFLUOROPHENYL)ACETAMIDE(64695-81-4)
• EPA Substance Registry System: N-(2-BROMO-4,5-DIFLUOROPHENYL)ACETAMIDE(64695-81-4)

Safety Data

• Hazardous Substances Data: 64695-81-4(Hazardous Substances Data)

Usage

General Description

N-(2-Bromo-4,5-difluorophenyl)acetamide is a chemical compound with the molecular formula C8H7BrF2NO. It is a white to off-white solid with a molecular weight of 243.05 g/mol. This chemical is commonly used in pharmaceutical and research applications. It has properties that make it useful for its potential antiviral and antibacterial properties. Additionally, it has been studied for its potential use in the treatment of various diseases. N-(2-Bromo-4,5-difluorophenyl)acetamide should be handled and used with proper safety precautions due to its potential health hazards.

InChI:InChI=1/C8H6BrF2NO/c1-4(13)12-8-3-7(11)6(10)2-5(8)9/h2-3H,1H3,(H,12,13)

Upstream product

• 3863-11-4 3,4-difluoroaniline 
• 458-11-7 3,4-difluoroacetanilide 
• 64695-79-0 2-bromo-4,5-difluoro-aniline 
• 108-24-7 acetic anhydride 

Downstream Products

• 80076-46-6 (+/-)-5,6-difluoro-2-methyl-1,2,3,4-tetrahydroquinoline 
• 170881-41-1 5,6-difluoro-2-methylbenzo[d]thiazole 
• 131190-82-4 8-bromo-5,6-difluoro-2-methylquinoline 

Relevant articles and documents

Synthesis and antileishmanial activity of fluorinated rhodacyanine analogues: The ‘fluorine-walk’ analysis

In a search for potent antileishmanial drug candidates, eighteen rhodacyanine analogues bearing fluorine or perfluoroalkyl substituents at various positions were synthesized. These compounds were tested for their inhibitory activities against Leishmania martiniquensis and L. orientalis. This ‘fluorine-walk’ analysis revealed that the introduction of fluorine atom at C-5, 6, 5′, or 6′ on the benzothiazole units led to significant enhancement of the activity, correlating with the less negative reduction potentials of the fluorinated analogues confirmed by the electrochemical study. On the other hand, [sbnd]CF3 and [sbnd]OCF3 groups were found to have detrimental effects, which agreed with the poor aqueous solubility predicted by the in silico ADMET analysis. In addition, some of the analogues including the difluorinated species showed exceptional potency against the promastigote and axenic amastigote stages (IC50 = 40–85 nM), with the activities surpassing both amphotericin B and miltefosine.