646995-45-1

Basic information

• Product Name: Cyclopropanecarboxylic acid, 2,2-difluoro-3-phenyl-, (1S,3S)-
• CAS NO: 646995-45-1
• Molecular Formula: C10H8F2O2
• Molecular Weight: 198.169
• Mol File: 646995-45-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Cyclopropanecarboxylic acid, 2,2-difluoro-3-phenyl-, (1S,3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanecarboxylic acid, 2,2-difluoro-3-phenyl-, (1S,3S)-(646995-45-1)
• EPA Substance Registry System: Cyclopropanecarboxylic acid, 2,2-difluoro-3-phenyl-, (1S,3S)-(646995-45-1)

Safety Data

• Hazardous Substances Data: 646995-45-1(Hazardous Substances Data)

Upstream product

• 82045-18-9 trans-(+/-)-2,2-difluoro-3-phenylcyclopropane-1-carboxylic acid 

Relevant articles and documents

Synthesis of high enantiomeric purity gem-dihalocyclopropane derivatives from biotransformations of nitriles and amides

Enantioselective biotransformations of geminally dihalogenated cyclopropanecarbonitriles and amides are described. Both the reaction rate and enantioselectivity of the nitrile hydratase and amidase involved in Rhodococcus sp. AJ270 microbial cells are strongly governed by the nature of gem-disubstituents on the cyclopropane ring; the amidase generally exhibits steric dependence on the substituents while both the steric and electronic factors of the substituents may affect the action of the nitrile hydratase. The match of steric bulkiness of the substituents at 2- with that at 3-positions on the cyclopropane ring benefits the efficient and highly enantioselective reaction. Coupled with facile chemical transformations, biocatalytic transformations of nitrile and amide supply an effective synthesis of optically active 2,2-disubstitued-3-phenylcyclopropanecarboxylic acid and amide in both enantiomeric forms.