82045-18-9

Upstream product

• 118138-22-0 trans-(+/-)-(2,2-difluoro-3-phenylcyclopropyl)methanol 
• 21040-45-9 Cinnamyl acetate 
• 742112-05-6 cinnamyloxy(triisopropylsilane) 
• 82045-06-5 1-(acetoxymethyl)-2,2-difluoro-3-phenylcyclopropane 

Downstream Products

• 15463-92-0 dimethyl 2-phenylsuccinate 
• 646995-44-0 (-)-(1R,3R)-2,2-difluoro-3-phenylcyclopropanecarboxamide 
• 646995-45-1 (+)-(1S,3S)-2,2-difluoro-3-phenylcyclopropanecarboxylic acid 
• 58641-87-5 (1R,2R)-trans-2-phenylcyclopropane-1-carboxamide 
• 928054-81-3 (1S,2S)-2-phenylcyclopropanecarboxamide 
• 646995-57-5 (+)-(1R,3R)-2,2-dichloro-3-phenylcyclopropanecarboxylic acid 
• 82045-10-1 trans-2,2-Difluoro-3-phenylcyclopropan-1-carbonsaeure-methylester 

Relevant academic research and scientific papers

Difluorocarbene Addition to Alkenes and Alkynes in Continuous Flow

The first in-flow difluorocarbene generation and addition to alkenes and alkynes is reported. The application of continuous flow technology allowed for the controlled generation of difluorocarbene from TMSCF3 and a catalytic quantity of NaI. Th

Studies on Organic Fluorine Compounds. 38. Ring-Opening Reactions of gem-Difluorocyclopropyl Ketones with Nucleophiles

Syntheses of gem-difluorocyclopropyl ketones (3a-d) and their reactions with nucleophiles are described.Ring-opening reaction of 3a,c,d having a hydrogen substituent at C1 adjacent to the carbonyl group with a methanolate anion gave carboxylic acid derivatives derived from C1-C2 bond scission (between the carbon atom with an acyl group and the carbon atom with fluorine substituents).On the other hand, reaction of 3a-c with a thiolate anion resulted in the C1-C3 bond cleavage (carbon-carbon bond opposite to the difluoromethylene group).