647014-44-6

Usage

Structure

Piperidine carboxylic acid ester with a tert-butyl group attached to the piperidine nitrogen

Usage

Intermediate in the synthesis of various pharmaceuticals and agrochemicals

Applications

Potential applications in medicinal and organic chemistry

Unique features

Presence of bromo and fluoro substituents on the phenyl ring makes it useful for the development of new materials and pharmacological agents.

Upstream product

• 496-69-5 2-bromo-4-fluoro-phenol 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 

Downstream Products

• 1189551-07-2 t-butyl 4-[4-fluoro-2-(morpholin-4-yl)phenoxy]piperidine-1-carboxylate 
• 1189551-22-1 t-butyl 4-[4-fluoro-2-(1-methyl-1H-pyrazol-4-yl)phenoxy]piperidine-1-carboxylate 
• 647014-45-7 4-(2-bromo-4-fluorophenoxy)piperidine 

Relevant academic research and scientific papers

HYDROXYQUINOXALINECARBOXAMIDE DERIVATIVE

The present invention provides a novel hydroxyquinoxaline carboxamide derivative that is useful for preventing and/or treating blood coagulation disorders. A compound represented by formula (i), or a pharmacologically acceptable salt thereof: wherein, each of R1 and R2 independently represents a group such as a hydrogen atom or a halogen atom; R3 represents a group such as a hydrogen atom; each of R4 and R5 independently represents a group such as a hydrogen atom, a halogen atom or a C1-4 alkyl group; each of R6 and R7 independently represents a hydrogen atom or a C1-4 alkyl group; X represents a group such as a C3-10 cycloalkyl group, C6-10 aryl group or a 5- to 10-membered heterocyclic group, which may be substituted with substituent(s) selected from substituent group α; Y represents a group such as -CO-, -O- or -NRa-, and Ra represents a group such as a hydrogen atom or a C1-4 alkyl group.

SULPHONYLPIPERIDINE DERIVATIVES CONTAINING AN ARYL OR HETEROARYL GROUP FOR USE AS MATRIX METALLOPROTEINASE INHIBITORS

A compound of formula (1), wherein B is an ortho substituted monocyclic aryl or heteroaryl group or a bicyclic aryl or heteroaryl group; useful in the inhibition of one or more metalloproteinases, and in particular TACE.