647014-95-7

Upstream product

• 400737-43-1 (2R,3S,4R,5R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-octanoic acid methoxy-methyl-amide 

Downstream Products

• 647014-98-0 (E)-(2R,4R,5S,6S,7R,12S,13S)-4,6,13-Tris-(tert-butyl-dimethyl-silanyloxy)-1,12-dimethoxy-2-(4-methoxy-benzyloxy)-5,7-dimethyl-octadec-9-en-16-yn-8-one 
• 647014-99-1 (E)-(2R,4R,5R,6S,7R,12S,13S)-4,13-Bis-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-1,12-dimethoxy-2-(4-methoxy-benzyloxy)-5,7-dimethyl-octadec-9-en-16-yn-8-one 
• 647014-97-9 [(3R,4S,5S,6R,8R)-4,6-Bis-(tert-butyl-dimethyl-silanyloxy)-9-methoxy-8-(4-methoxy-benzyloxy)-3,5-dimethyl-2-oxo-nonyl]-phosphonic acid dimethyl ester 
• 647014-96-8 [(3R,4S,5R,6R,8R)-6-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-9-methoxy-8-(4-methoxy-benzyloxy)-3,5-dimethyl-2-oxo-nonyl]-phosphonic acid dimethyl ester 

Relevant academic research and scientific papers

Total Synthesis of Apoptolidin: Completion of the Synthesis and Analogue Synthesis and Evaluation

The total synthesis of apoptolidin (1) is reported together with the design, synthesis, and biological evaluation of a number of analogues. The assembly of key fragments 6 and 7 to vinyl iodide 3 via dithiane coupling technology was supplemented by a seco