647014-99-1

Upstream product

• 647014-95-7 [(3R,4S,5S,6R,8R)-6-(tert-Butyl-dimethyl-silanyloxy)-9-methoxy-8-(4-methoxy-benzyloxy)-3,5-dimethyl-2-oxo-4-trimethylsilanyloxy-nonyl]-phosphonic acid dimethyl ester 
• 647014-96-8 [(3R,4S,5R,6R,8R)-6-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-9-methoxy-8-(4-methoxy-benzyloxy)-3,5-dimethyl-2-oxo-nonyl]-phosphonic acid dimethyl ester 
• 400737-46-4 (2R,3S,4S,5R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-3-trimethylsilanyloxy-octanoic acid methoxy-methyl-amide 
• 400737-43-1 (2R,3S,4R,5R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-octanoic acid methoxy-methyl-amide 
• 268736-76-1 tert-Butyl-[(S)-1-((S)-1-methoxy-but-3-enyl)-hex-4-ynyloxy]-dimethyl-silane 
• 647014-94-6 (3S,4S)-4-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-non-7-ynal 
• 647014-97-9 [(3R,4S,5S,6R,8R)-4,6-Bis-(tert-butyl-dimethyl-silanyloxy)-9-methoxy-8-(4-methoxy-benzyloxy)-3,5-dimethyl-2-oxo-nonyl]-phosphonic acid dimethyl ester 

Relevant academic research and scientific papers

Total Synthesis of Apoptolidin: Completion of the Synthesis and Analogue Synthesis and Evaluation

The total synthesis of apoptolidin (1) is reported together with the design, synthesis, and biological evaluation of a number of analogues. The assembly of key fragments 6 and 7 to vinyl iodide 3 via dithiane coupling technology was supplemented by a seco