64705-37-9

Basic information

• Product Name: 2-(2-IODO-4,5-DIMETHOXY-PHENYL)-ETHANOL
• Synonyms: 2-(2-IODO-4,5-DIMETHOXY-PHENYL)-ETHANOL
• CAS NO: 64705-37-9
• Molecular Formula: C₁₀H₁₃IO₃
• Molecular Weight: 308.11289
• Mol File: 64705-37-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 369.6°C at 760 mmHg
• Flash Point: 177.3°C
• Appearance: /
• Density: 1.623g/cm³
• Vapor Pressure: 4.09E-06mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: 2-(2-IODO-4,5-DIMETHOXY-PHENYL)-ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-IODO-4,5-DIMETHOXY-PHENYL)-ETHANOL(64705-37-9)
• EPA Substance Registry System: 2-(2-IODO-4,5-DIMETHOXY-PHENYL)-ETHANOL(64705-37-9)

Safety Data

• Hazardous Substances Data: 64705-37-9(Hazardous Substances Data)

Usage

Physical form

White crystalline solid

Common uses

Organic synthesis, pharmaceutical research

Potential pharmacological properties

Antimicrobial, anti-inflammatory effects

Industrial uses

Production of pharmaceutical drugs, intermediate in synthesis of other organic compounds

Safety precautions

Potential risks to human health and the environment, handle with caution

InChI:InChI=1/C10H13IO3/c1-13-9-5-7(3-4-12)8(11)6-10(9)14-2/h5-6,12H,3-4H2,1-2H3

Upstream product

• 7417-21-2 2-(3,4-dimethoxyphenyl)ethyl alcohol 
• 35323-09-2 (2-iodo-4,5-dimethoxyphenyl)acetic acid 
• 35345-49-4 2-iodo-4,5-dimethoxyphenylacetic acid methyl ester 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 

Downstream Products

• 64728-24-1 2-Jod-4,5-dimethoxy-phenaethylchlorid 
• 452056-09-6 2-(2-iodo-4,5-dimethoxyphenyl)acetaldehyde 
• 10605-02-4 palmatine chloride 
• 250642-96-7 2-(2-iodo-4,5-dimethoxyphenyl)ethyl methanesulfonate 
• 64705-38-0 2-Jod-4,5-dimethoxy-phenaethyljodid 

Relevant articles and documents

Modular and Divergent Syntheses of Protoberberine and Protonitidine Alkaloids

A modularly convergent and divergent strategy was established for the family synthesis of both protoberberine and protonitidine alkaloids. The robust, scalable, and flexible synthetic route featured a collective preparation of protoberberine and protonitidine alkaloids from a common isoquinoline assembled from pyridyne as the key synthon, which was based on the selective N-C or C-C cyclization via distinct processes. Through the strategy, 20 protoberberine alkaloids, 5 protonitidine alkaloids, and 11 analogues with diverse substituents were comprehensively aquired.

Synthesis of Functionalized Indolines and Dihydrobenzofurans by Iron and Copper Catalyzed Aryl C-N and C-O Bond Formation

A simple and effective one-pot, two-step intramolecular aryl C-N and C-O bond forming process for the preparation of a wide range of benzo-fused heterocyclic scaffolds using iron and copper catalysis is described. Activated aryl rings were subjected to a highly regioselective, iron(III) triflimide-catalyzed iodination, followed by a copper(I)-catalyzed intramolecular N-or O-arylation step leading to indolines, dihydrobenzofurans, and six-membered analogues. The general applicability and functional group tolerance of this method were exemplified by the total synthesis of the neolignan natural product, (+)-obtusafuran. DFT calculations using Fukui functions were also performed, providing a molecular orbital rationale for the highly regioselective arene iodination process.

Catalytic Cyclization of o-Alkynyl Phenethylamines via Osmacyclopropene Intermediates: Direct Access to Dopaminergic 3-Benzazepines

A novel osmium-catalyzed cyclization of o-alkynyl phenethylamines to give 3-benzazepines is reported. The procedure allows the straightforward preparation of a broad range of dopaminergic 3-benzazepine derivatives. Mechanistic investigations revealed that the process takes place via osmacyclopropene intermediates, which were isolated and characterized by X-ray crystallography.