64728-49-0

Basic information

• Product Name: 1,4-DI(2-PYRIDYL)PIPERAZINE
• Synonyms: 1,4-DI(2-PYRIDYL)PIPERAZINE;Dipyridylpiperazine;Nsc28698
• CAS NO: 64728-49-0
• Molecular Formula: C₁₄H₁₆N₄
• Molecular Weight: 240.3
• Mol File: 64728-49-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 127 °C
• Appearance: /
• CAS DataBase Reference: 1,4-DI(2-PYRIDYL)PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-DI(2-PYRIDYL)PIPERAZINE(64728-49-0)
• EPA Substance Registry System: 1,4-DI(2-PYRIDYL)PIPERAZINE(64728-49-0)

Safety Data

• Hazardous Substances Data: 64728-49-0(Hazardous Substances Data)

Usage

General Description

1,4-Di(2-pyridyl)piperazine (DPPI) is a chemical compound that belongs to the piperazine family. It is a heterocyclic compound with a molecular formula C12H14N4 and a molecular weight of 214.27 g/mol. DPPI is commonly used as a building block in the synthesis of pharmaceutical and agrochemical products. It has potential applications in the development of new drugs and as a ligand in coordination chemistry. DPPI has also been investigated for its potential role in cancer therapy and as a treatment for neurodegenerative diseases. However, it is important to handle this compound with care due to its potential toxicity and hazardous properties.

Upstream product

• 110-85-0 piperazine 
• 109-04-6 2-bromo-pyridine 
• 372-48-5 2-fluoropyridine 
• 109-09-1 2-chloropyridine 
• 15103-48-7 pyridine-2-sulfonic acid 

Relevant articles and documents

Metallation versus heteroatom lithium complexation: Mono- and dilithiation of dipyridylpiperazines

BuLi-LiDMAE induced the efficient lithiation of dipyridylpiperazines despite strong competing lithium coordination by several nitrogen atoms. Symmetrical substrates led to a one-pot dilithiation while dissymmetrical species gave mono- or dilithiation under temperature control. Georg Thieme Verlag Stuttgart.

Amination of 2-Pyridinesulfonic and 8-Quinolinesulfonic Acids with Magnesium Amides

The amination of 2-pyridine- and 8-quinolinesulfonic acids using magnesium amides of the type R2NMgCl·LiCl is reported. Thus, several cyclic and acyclic amines were converted into the corresponding amides using iPrMgCl·LiCl, which reacted readily with sulfonic acids to produce aminopyridines and aminoquinolines. Various amines which are attractive in drug chemistry were suitable for this transformation.

Nickel-mediated amination chemistry. Part 2: Selective N-arylation or N,N'-diarylation of piperazine

The 2,2'-bipyridine liganded Ni catalyst has revealed a good selectivity in the mono arylation of piperazine starting from aryl chlorides allowing a selective and efficient synthesis of N-arylpiperazines using stoichiometric amounts of reagents. The preparation of N,N'-diaryl substituted piperazines is also described. (C) 2000 Elsevier Science Ltd.