64728-49-0

Basic information

• Product Name: 1,4-DI(2-PYRIDYL)PIPERAZINE
• Synonyms: 1,4-DI(2-PYRIDYL)PIPERAZINE;Dipyridylpiperazine;Nsc28698
• CAS NO: 64728-49-0
• Molecular Formula: C₁₄H₁₆N₄
• Molecular Weight: 240.3
• Mol File: 64728-49-0.mol

Chemical Properties

• Melting Point: 127 °C
• Appearance: /
• CAS DataBase Reference: 1,4-DI(2-PYRIDYL)PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-DI(2-PYRIDYL)PIPERAZINE(64728-49-0)
• EPA Substance Registry System: 1,4-DI(2-PYRIDYL)PIPERAZINE(64728-49-0)

Safety Data

• Hazardous Substances Data: 64728-49-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
1,4-Di(2-pyridyl)piperazine is used as a building block for the synthesis of various pharmaceutical and agrochemical products, contributing to the development of new drugs and agrochemicals with improved efficacy and safety profiles.
Used in Coordination Chemistry:
DPPI is utilized as a ligand in coordination chemistry, playing a crucial role in the formation of metal complexes with potential applications in catalysis, sensing, and materials science.
Used in Cancer Therapy:
1,4-Di(2-pyridyl)piperazine has been investigated for its potential role in cancer therapy, with research focusing on its ability to target and inhibit specific biological processes involved in cancer cell growth and proliferation.
Used in Neurodegenerative Disease Treatment:
DPPI is also being explored as a potential treatment for neurodegenerative diseases, with studies examining its capacity to modulate neuroprotective pathways and alleviate disease-associated symptoms.

Upstream product

• 110-85-0 piperazine 
• 109-09-1 2-chloropyridine 
• 15103-48-7 pyridine-2-sulfonic acid 
• 372-48-5 2-fluoropyridine 
• 109-04-6 2-bromo-pyridine 

Relevant articles and documents

Metallation versus heteroatom lithium complexation: Mono- and dilithiation of dipyridylpiperazines

BuLi-LiDMAE induced the efficient lithiation of dipyridylpiperazines despite strong competing lithium coordination by several nitrogen atoms. Symmetrical substrates led to a one-pot dilithiation while dissymmetrical species gave mono- or dilithiation under temperature control. Georg Thieme Verlag Stuttgart.

SYNTHESIS OF NEW ARMED CYCLOPOLYAMINES AND THEIR SELECTIVE EXTRACTION PROPERTIES FOR METAL IONS

A variety of new armed cyclopolyamines were prepared by high presure SNAr reactions (0.8 GPa, 100 deg C) of cyclopolyamines with heteroaromatic halides.Certain of these agents show selective extraction properties for Hg2+ and Ag+ ions.

Amination of 2-Pyridinesulfonic and 8-Quinolinesulfonic Acids with Magnesium Amides

The amination of 2-pyridine- and 8-quinolinesulfonic acids using magnesium amides of the type R2NMgCl·LiCl is reported. Thus, several cyclic and acyclic amines were converted into the corresponding amides using iPrMgCl·LiCl, which reacted readily with sulfonic acids to produce aminopyridines and aminoquinolines. Various amines which are attractive in drug chemistry were suitable for this transformation.

Nickel-catalysed selective N-arylation or N,N′-diarylation of secondary diamines

The selective synthesis of N-aryl or N,N′-diaryl piperazines and trimethylene(bis)piperidines from the corresponding diamines and aryl chlorides using a catalyst combination of Ni(0) associated to 2,2′-bipyridine is described. The Ni/2,2′-bipyridine catalyst is also effective for the sequential arylation of piperazine. The preparation of novel and unsymmetrical 1,4-diaryl piperazines is reported.

Nickel-mediated amination chemistry. Part 2: Selective N-arylation or N,N'-diarylation of piperazine

The 2,2'-bipyridine liganded Ni catalyst has revealed a good selectivity in the mono arylation of piperazine starting from aryl chlorides allowing a selective and efficient synthesis of N-arylpiperazines using stoichiometric amounts of reagents. The preparation of N,N'-diaryl substituted piperazines is also described. (C) 2000 Elsevier Science Ltd.