6475-17-8

Basic information

• Product Name: N-cyclohexyl-N-(cyclohexylcarbamoyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide
• CAS NO: 6475-17-8
• Molecular Formula: C₂₃H₂₉N₃O₄
• Molecular Weight: 411.4941
• Mol File: 6475-17-8.mol
• Article Data: 1

Chemical Properties

• Density: 1.28g/cm³
• Refractive Index: 1.611
• CAS DataBase Reference: N-cyclohexyl-N-(cyclohexylcarbamoyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclohexyl-N-(cyclohexylcarbamoyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide(6475-17-8)
• EPA Substance Registry System: N-cyclohexyl-N-(cyclohexylcarbamoyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide(6475-17-8)

Safety Data

• Hazardous Substances Data: 6475-17-8(Hazardous Substances Data)

Upstream product

• 4702-13-0 N-phthaloylglycine 
• 538-75-0 dicyclohexyl-carbodiimide 

Relevant articles and documents

Synthesis of quinazolindionyl amino acid and hydrazone derivatives as possible antitumour agents

A series of 1-ethyl-2,4-dioxo-(1H,3H)-quinazolin-3-yl amino acid and hydrazone derivatives were synthesized and tested for their antitumor activity. The alcohol and acid derivatives of quinazolindione were conjugated with the amino acid derivatives at N-3 site via ester or amide bonds by carbodiimide and azide methods. The carbodiimide-mediated amide and esterification steps were performed in the presence of HOBt or DMAP respectively otherwise the side-products N-acyl urea derivatives are formed, instead of the desired derivatives. Nine compounds exhibited encouraging antitumor activity against human liver carcinoma cell line (HepG2).