64750-89-6Relevant academic research and scientific papers
Synthesis of new β-trifluoromethyl containing GABA and β-fluoromethyl containing N-benzylpyrrolidinones
Gerus, Igor I.,Mironets, Roman V.,Shaitanova, Elena N.,Kukhar, Valery P.
scheme or table, p. 224 - 228 (2010/04/30)
A whole series of 3-(mono-, di-, trifluoro)methyl-substituted N-benzylpyrrolidinones 5a-c was synthesized by deoxyfluorination of corresponding 3-functionalized N-benzylpyrrolidinones. New β-trifluoromethyl containing GABA 4a was obtained in two alternative ways: by successive hydrolysis and hydrogenolysis of 3-trifluoromethyl N-benzylpyrrolidinone 5a and from trifluoroacetone as starting compound.
1-Bromo-3-trifluoromethylbut-2-ene: synthesis and electrophilic reactivity
Martin, Valerie,Molines, Huguette,Wakselman, Claude
, p. 63 - 68 (2007/10/02)
A three-step synthesis of 1-bromo-3-trifluoromethylbut-2-ene in 54percent overall yield is reported starting from 1,1,1-trifluoroacetone.The electrophilic reactivity of this compound towards various nucleophiles has been studied.Thus, for example, condensation with the sodium salt of diethyl malonate gave ethyl 2-carboethoxy-5-trifluoromethylhex-4-enoate in 66percent yield.
Antiinflammatory activity of a series of substituted 2,3-dihydro-6-hydroxypyrimido[2,1-f]purine-4,8(1H,9H)-diones
Kaminski,Solomon,Conn,Wong,Chiu,Massa,Siegel,Watnick
, p. 1118 - 1127 (2007/10/02)
A series of substituted analogues based on the novel 2,3-dihydro-6-hydroxypyrimido[2,1-f]purine-4,8(1H,9H)-dione ring system have been synthesized and shown to exhibit antiinflammatory activity in the adjuvant-induced arthritis rat model (AAR). The activi
Efforts in Synthesizing α,β-Unsaturated Trifluoromethyl-substituted Aldehydes
Abele, Herbert,Haas, Alois,Lieb, Max
, p. 3502 - 3506 (2007/10/02)
Hexafluoroacetone reacts with ethynylmagnesium bromide to yield (CF3)2C(OH)-CCH (1).Bromine can be added to the triple bond affording the cis/trans-isomer 2.With PCl5 1 yields the allene (CF3)2C=C=CClH (3).The addition of a metalated Schiff base to hexafluoroacetone leads to 4a which on hydrolysis yields (CF3)2C(OH)-CH2-CHO (4b).The reaction of (EtO)2P(O)CH2-R (R = CHO, CO2Et) with hexafluoroacetone gives α,β-unsaturated aldehydes or esters 6. 1,1,1-Trifluoroacetone provides analogous reactions.
Synthesis and Thermolysis of Highly Halogenated Δ1-Pyrazolines
Huff, Roger K.,Savins, Eric G.
, p. 742 - 743 (2007/10/02)
The pyrolysis of highly halogenated Δ1-pyrazolines gives, in addition to cyclopropanes, rearranged olefins.
