64753-81-7

Basic information

• Product Name: [6R-(6alpha,7beta)]-7-(aminophenylacetamido)-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• Synonyms: [6R-(6alpha,7beta)]-7-(aminophenylacetamido)-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;(6R,6β)-7α-[[(Amino)phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• CAS NO: 64753-81-7
• Molecular Formula: C₁₅H₁₄ClN₃O₄S
• Molecular Weight: 367.80736
• EINECS: 265-216-1
• Mol File: 64753-81-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 713.4±60.0 °C(Predicted)
• Appearance: /
• Density: 1.62±0.1 g/cm3(Predicted)
• PKA: 1.95±0.50(Predicted)
• CAS DataBase Reference: [6R-(6alpha,7beta)]-7-(aminophenylacetamido)-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [6R-(6alpha,7beta)]-7-(aminophenylacetamido)-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid(64753-81-7)
• EPA Substance Registry System: [6R-(6alpha,7beta)]-7-(aminophenylacetamido)-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid(64753-81-7)

Safety Data

• Hazardous Substances Data: 64753-81-7(Hazardous Substances Data)

Usage

General Description

The chemical [6R-(6alpha,7beta)]-7-(aminophenylacetamido)-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is a complex compound with a specific molecular structure. It is classified as a cephalosporin antibiotic, which means it is utilized for the treatment of bacterial infections. The chemical has a unique 7-(aminophenylacetamido) side chain attached to a central 1-azabicyclo[4.2.0]octane ring, and a carboxylic acid group. The presence of the chlorine, thia, and oxo functional groups also provide distinctive properties to the compound. Due to its complex structure and specific functional groups, the chemical exhibits potent antibacterial activity against a range of organisms, making it a valuable tool in the treatment of various infections.

Upstream product

• 53994-69-7 (6R,7R)-1-aza-3-chloro-7-amino-8-oxo-5-thiabicyclo<4.2.0>oct-2-ene-2-carboxylic acid 
• 24461-61-8 (R)-Phenylglycine methyl ester 
• 700-63-0 (R)-phenylglycine amide 
• 53994-76-6 (6R)-7t-((R)-2-amino-2-phenyl-acetylamino)-3-chloro-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester; toluene-4-sulfonate 

Downstream Products

• 2882-18-0 2-hydroxy-3-phenylpyrazine 

Relevant articles and documents

Cefaclor preparation and preparation method thereof

The invention discloses a cefaclor preparation and a preparation method thereof. The preparation method comprises: preparing cefaclor crystal, pretreating a main material and auxiliary materials, weighing, mixing, forming, and packaging; wherein the preparation of the cefaclor crystal includes subjecting 7-ACCA and potassium (R)-[(3-ethoxy-1-methyl-3-oxoprop-1-enyl)amino]phenylacetate to silylation, acylation, condensation, acid hydrolysis, extraction and cleaning, decoloring, and crystallization; the preparation comprises the cefaclor crystal as the main material and auxiliary materials, the cefaclor crystal is /=33 degrees in angle of repose, 0.50-0.60 g/m in bulk density, 0.70-0.80 g/ml in compactness and 40-60 Mum in D10 of particle size distribution, 120-140 Mum in D50 and 210-230 Mum in D90. The conversion rate of cefaclor in chemical synthesis is increased, reaction conditions are simplified, the crystal form and particle size distribution of the cefaclor crystal are improved, and the quality of finished cefaclor crystal is improved.

Process for the preparation of 3-chloro-cefem compounds

The process comprises a series of stages essentially comprising the protection of the functional groups of the side chain of Ampicillin, esterification of the acid group, oxidation to sulphoxide, expansion of the thiazole ring to a thiazine ring, ozonolysis of the exomethylene cefam derivative obtained, substitution of the hydroxyl group by chlorine and de-protection of the functional groups, in which the order of some stages can be varied without affecting the final result.