64754-68-3

Basic information

• Product Name: 2-chloro-N-methyl-N-phenylpropanamide
• CAS NO: 64754-68-3
• Molecular Formula: C₁₀H₁₂ClNO
• Molecular Weight: 197.6614
• Mol File: 64754-68-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 273.5°C at 760 mmHg
• Flash Point: 119.2°C
• Density: 1.167g/cm³
• Vapor Pressure: 0.00571mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: 2-chloro-N-methyl-N-phenylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-methyl-N-phenylpropanamide(64754-68-3)
• EPA Substance Registry System: 2-chloro-N-methyl-N-phenylpropanamide(64754-68-3)

Safety Data

• Hazardous Substances Data: 64754-68-3(Hazardous Substances Data)

Upstream product

• 100-61-8 N-methylaniline 
• 7623-09-8 2-chloropropionyl chloride 

Downstream Products

• 1309366-71-9 (R)-N-methyl-N-(2-methyloctyl)aniline 
• 1309366-69-5 (S)-N-methyl-N-(2-methyloctyl)aniline 
• 31367-67-6 N-(2-chloropropyl)-N-methylaniline 
• 1309366-91-3 C₂₀H₂₇NO 
• 10545-45-6 N-isopropyl-N-methylaniline 

Relevant articles and documents

Transfer Hydro-dehalogenation of Organic Halides Catalyzed by Ruthenium(II) Complex

A simple and efficient Ru(II)-catalyzed transfer hydro-dehalogenation of organic halides using 2-propanol solvent as the hydride source was reported. This methodology is applicable for hydro-dehalogenation of a variety of aromatic halides and α-haloesters and amides without additional ligand, and quantitative yields were achieved in many cases. The potential synthetic application of this method was demonstrated by efficient gram-scale transformation with catalyst loading as low as 0.5 mol %.

A New and Practical Synthesis of Indolones

A variety of indolones can be obtained from α-haloanilides through a radical cyclisation mediated by a combination of nickel powder and acetic acid.