64757-26-2

Usage

Appearance

Yellow crystalline powder The compound's physical form is a yellow-colored solid with a crystalline structure.

Pharmaceutical industry use

Intermediate in drug synthesis 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl thiocyanate is utilized as a precursor in the production of various pharmaceutical drugs.

Anti-microbial properties

Effective against microorganisms The compound exhibits properties that help combat and inhibit the growth of microorganisms, such as bacteria and fungi.

Anti-malarial properties

Useful in treating malaria The compound is known for its ability to fight against the Plasmodium parasites responsible for causing malaria.

Thiocyanate group

Strong bonding with metal ions The presence of a thiocyanate group in the compound's structure allows it to form stable complexes with metal ions, which is valuable in coordination chemistry.

Imidazol-1-yl group

Indication of biological activity The presence of this group in the compound's structure suggests potential biological activity, making it a promising candidate for further research and pharmaceutical applications.

Upstream product

• 443-48-1 metronidazole 
• 540-72-7 sodium thiocyanide 
• 6058-57-7 1-(2-bromoethyl)-2-methyl-5-nitroimidazole 

Relevant academic research and scientific papers

A treating agent temp.and for water treatment and preparation method thereof

The invention relates to a biological slime treating agent for water treatment and a preparation method of the biological slime treating agent. The biological slime treating agent comprises the following components in percentage by weight: 5-30% of 1-(2-thiocyano)ethyl-2-methyl-3-benzyl-5-nitroimidazole, 5-10% of N,N-bis(dodecyldimethyl)-3-oxa-1,5-pentadiammonium dichloride, 5-10% of dithiocyanomethane, 1-10% of isothiazolinone, 1-10% of organochlorine, 5-40% of a solvent and the balance of water. The preparation method of the biological slime treating agent is as follows: at room temperature, adding 1-(2-thiocyano)ethyl-2-methyl-3-benzyl-5-nitroimidazole, N,N-bis(dodecyldimethyl)-3-oxa-1,5-pentadiammonium dichloride and water into a reactor, adjusting the pH value to less than 6 with hydrochloric acid, adding an alcohol solvent, uniformly stirring, adding isothiazolinone and organochlorine and stirring until isothiazolinone and organochlorine are completely dissolved to obtain the biological slime treating agent. The biological slime treating agent has good bactericidal property, can be widely used in industrial circulating water treatment and especially can be suitable for controlling the breeding of bacteria such as SRB in an oily wastewater system of an oilfield.

Chemotherapeutically active nitro compounds, 4, 5-nitroimidazoles (part I)

More than 135 new 2-methyl-5-nitroimidazoles substituted in 1-position and 1-methyl-5-nitroimidazoles substituted in 2-position were investigated for their activity against various protozoan species, in particular Entamoeba histolytica in the golden hamster, Trichomonas fetus, Trypanosoma brucei and T. cruzi in the NMRI mouse. Among the nitroimidazoles substituted in the 1-position only two preparations exhibited a similar effect as metronidazole against T. fetus. In the class of the nitroimidazoles substituted in the 2-position 16 compounds were as effective as metronidazole, 19 showed an effect superior to metronidazole, 1 was as good as tinidazole and 2 exhibited an activity superior to tinidazole against T. fetus. Only few compounds displayed any amoebicidal activity. Of the mono and bis-hydrazones of 1-methyl-5-nitroimidazole-2-aldehyde substituted in the 2-position 3 compounds had an amoebicidal effect 2 to 8 times stronger than that of metronidazole. Only few representatives of the 1-methyl-5-nitroimidazoles substituted in the 2-position produced a useful trypanocidal effect when given in relatively high doses. The structure-activity relationship of 5-nitroimidazole derivatives has been discussed.