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L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 64769-66-0 Structure
  • Basic information

    1. Product Name: L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID
    2. Synonyms: L-TRANS-4-CARBOXY-L-PROLINE;L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID;L-TRANS-2,4-PDC;TRANS-4-CARBOXY-L-PROLINE;2,4-Pyrrolidinedicarboxylicacid,(2S,4R)-(9CI);Zinc03796127;(2S,4R)-pyrrolidine-2,4-dicarboxylic acid
    3. CAS NO:64769-66-0
    4. Molecular Formula: C6H9NO4
    5. Molecular Weight: 159.14
    6. EINECS: N/A
    7. Product Categories: PYRROLE;Glutamate receptor
    8. Mol File: 64769-66-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 355.3 °C at 760 mmHg
    3. Flash Point: 168.7 °C
    4. Appearance: /
    5. Density: 1.456 g/cm3
    6. Vapor Pressure: 5.28E-06mmHg at 25°C
    7. Refractive Index: 1.534
    8. Storage Temp.: Store at RT
    9. Solubility: Water (Slightly)
    10. CAS DataBase Reference: L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID(CAS DataBase Reference)
    11. NIST Chemistry Reference: L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID(64769-66-0)
    12. EPA Substance Registry System: L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID(64769-66-0)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 26-36
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 64769-66-0(Hazardous Substances Data)

64769-66-0 Usage

Uses

L-trans-Pyrrolidine-2,4-dicarboxylic Acid is an inhibitor of the glutamate transporter EAAT.

Biological Activity

Potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset? .

Check Digit Verification of cas no

The CAS Registry Mumber 64769-66-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,7,6 and 9 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 64769-66:
(7*6)+(6*4)+(5*7)+(4*6)+(3*9)+(2*6)+(1*6)=170
170 % 10 = 0
So 64769-66-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H9NO4/c8-5(9)3-1-4(6(10)11)7-2-3/h3-4,7H,1-2H2,(H,8,9)(H,10,11)/t3-,4+/m1/s1

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  • Sigma

  • (P7575)  L-trans-Pyrrolidine-2,4-dicarboxylic acid  ≥98%

  • 64769-66-0

  • P7575-2MG

  • 595.53CNY

  • Detail
  • Sigma

  • (P7575)  L-trans-Pyrrolidine-2,4-dicarboxylic acid  ≥98%

  • 64769-66-0

  • P7575-10MG

  • 1,966.77CNY

  • Detail

64769-66-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S,4R)-pyrrolidine-2,4-dicarboxylic acid

1.2 Other means of identification

Product number -
Other names L-trans-pyrrolidine-2,4-dicarboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:64769-66-0 SDS

64769-66-0Downstream Products

64769-66-0Relevant articles and documents

Asymmetric synthesis of 2,4-disubstituted pyrrolidines

Wang, Qian,Sasaki, N. Andre,Potier, Pierre

, p. 5755 - 5758 (2007/10/03)

A new strategy for asymmetric synthesis of 2,4-disubstituted pyrrolidines is described, starting from readily available chiral building blocks 1 and (2R)-2,3-O-isopropylideneglycealdehyde (6).

Asymmetric synthesis of 4-substituted prolines as conformationally constrained amino acid analogues

Wang, Qian,Sasaki, N. Andre,Potier, Pierre

, p. 15759 - 15780 (2007/10/03)

Treatment of readily available chiral building block 1 with (2R)-2,3-O- isopropylideneglyceraldehyde (5) provides a new route for asymmetric synthesis of 2,4-disubstituted pyrrolidines. Several proline-amino acid chimeras: proline-leucine, proline-lysine, proline-arginine and proline- glutamic acid, are synthesized in highly diastereomerically pure forms.

Stereospecific synthesis of cis-2,4-pyrrolidinedicarboxylic acid and cis-2,5-piperidinedicarboxylic acid

Arakawa, Yasushi,Yasuda, Mika,Ohnishi, Masafumi,Yoshifuji, Shigeyuki

, p. 255 - 259 (2007/10/03)

Lactams derived from hetero Diels-Alder adducts were stereospecifically converted into cis-2,4-pyrrolidinedicarboxylic acid and cis-2,5- piperidinedicarboxylic acid by ruthenium tetroxide oxidation. Optically active (2S,4S)-(-)-2,4-pyrrolidinedicarboxylic acid and (2R,4R)-(+)-2,4- pyrrolidinedicarboxylic acid were synthesized from (1S,4R)-(+)-2- azabicyclo[2.2.1]hept-5-en-3-one and (1R,4S)-(-)-2-azabicyclo[2.2.1]hept-5- en-3-one, respectively.

An enantioselective route to pyrrolidines: Removal of the chiral template from homochiral pyrroloimidazoles

Jones, Raymond C. F.,Howard, Kevin J.,Snaith, John S.

, p. 1711 - 1714 (2007/10/03)

Two-step reductive removal of the chiral template from optically active pyrroloimidazoles, available from 1,3-dipolar cycloaddition of homochiral imidazolinium ylides, gives optically active substituted pyrrolidines. Selective manipulation of the substituents affords, e.g. naturally occurring proline derivatives and homochiral pyrrolizidines.

Conformationally Defined Neurotransmitter Analogues. Selective Inhibition of Glutamate Uptake by One Pyrrolidine-2,4-dicarboxylate Diastereomer

Bridges, Richard J.,Stanley, Mark S.,Anderson, Michael W.,Cotman, Carl W.,Chamberlin, A. Richard

, p. 717 - 725 (2007/10/02)

In order to determine the conformational requirements for binding of L-glutamate to the proteins involved in the process of neurotransmission, rigid analogues containing an embedded glutamate moiety have been prepared.These "conformer mimics", the pyrrolidine-2,4-dicarboxylates 4, 7, 11, and 14, were synthesized from commercially available trans-4-hydroxy-L-proline and cis-4-hydroxy-D-proline, and then were tested for their ability to inhibit the high-affinity transport of -L-glutamate into synaptosomes and to block the binding of radioligands to the NMDA (N-methyl-D-aspartate), KA (kainate), and QA (quisqualate) glutamate neurotransmitter receptor sites.While none of the four analogues binds effectively to the excitatory receptors, the L-trans-isomer 7 is a potent and selective competitive inhibitor of L-glutamate transport.These results delineate a specific structural/conformational preference for binding to the uptake system that is distinct from that required for binding to the NMDA, KA, and QA receptors.

Synthesis of two cyclic analogs of glutamic acid: cis- and trans-pyrrolidine-2,4-dicarboxylic acids

Trigalo, Franois,Molliex, Christophe,Champion, Brigitte,Azerad, Robert

, p. 3049 - 3050 (2007/10/19)

The tosyl ester 2 of tetraethyl 1-acetamido-4-hydroxybutane- 1,1,3,3-tetracarboxylate gave 4-methylene glutammic acid in 90% yield by refluxing with concentrated HC1. Treatment of 2 with NaOEt, then with refluxing concentrated HC1 gave a 54% yield of cis

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