6671-85-8

Usage

Uses

Used in Chemical Industry:
2-Azabicyclo[2.2.1]hept-5-ene is used as a monomer in polymerization reactions for the production of polymers with high impact resistance and heat resistance. Its unique structure contributes to the creation of materials that can withstand extreme conditions.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 2-Azabicyclo[2.2.1]hept-5-ene serves as a starting material for the synthesis of various drugs. Its reactivity and structural features make it an ideal candidate for the development of new medicinal compounds.
Used in Organic Synthesis:
2-Azabicyclo[2.2.1]hept-5-ene is used as an intermediate in the synthesis of bicycles and other complex organic compounds. Its ability to undergo various chemical reactions, such as polymerization, cycloaddition, and hydrogenation, enhances its versatility in organic synthesis.
Used in Industrial Chemical Production:
As a key component in the production of industrial chemicals, 2-Azabicyclo[2.2.1]hept-5-ene is utilized for its capacity to form a variety of chemical products that are essential in different sectors, including manufacturing and materials science.

InChI:InChI=1/C6H9N/c1-2-6-3-5(1)4-7-6/h1-2,5-7H,3-4H2

Upstream product

• 83953-54-2 2-azanorbornadiene 
• 542-92-7 cyclopenta-1,3-diene 
• 50-00-0 formaldehyd 
• 49805-30-3 racemic 2-azabicyclo[2.2.1]hept-5-en-3-one 
• 2053-29-4 methyleneamine 
• 49805-30-3 2-azabicyclo[2.2.1.]hept-5-en-3-one 

Downstream Products

• 140927-07-7 2-(carbobenzyloxy)-2-azabicyclo<2.2.1>hept-5-ene 
• 81640-21-3 2-Benzoyloxy-2-azabicyclo<2.2.1>hept-5-en 
• 139927-14-3 (+/-)-2-benzoyl-2-azabicyclo<2.2.1>hept-5-ene 
• 81640-21-3 2exo-(Benzoyloxy)-2-azabicyclo<2.2.1>hept-5-en 
• 81640-21-3 2endo-(Benzoyloxy)-2-azabicyclo<2.2.1>hept-5-en 
• 81640-22-4 N-hydroxy-2-azabicyclo<2.2.1>hept-5-ene 
• 81640-26-8 3-Benzoyl-2-oxa-3-azabicyclo<3.3.0>oct-7-en 
• 81640-24-6 3-(4-Methylphenylsulfonyl)-2-oxa-3-azabicyclo<3.3.0>oct-7-en 
• 81640-25-7 3-(4-Methylphenylsulfonyl)-2-oxa-3-azabicyclo<3.2.1>oct-6-en 
• 81640-27-9 N-Hydroxy-N-(4-methoxy-cyclopent-2-enylmethyl)-4-methyl-benzenesulfonamide 
• 81640-28-0 N-Hydroxy-N-(2-methoxy-cyclopent-3-enylmethyl)-4-methyl-benzenesulfonamide 
• 139927-14-3 2-benzoyl-2-azabicyclo<2.2.1>hept-5-ene 
• 286947-21-5 2-[(2-nitrophenyl)sulfonyl]-2-azabicyclo[2.2.1]hept-5-ene 
• 140927-17-9 2,2-Diphenyl-propionic acid (1R,4R,5R)-2-methyl-2-aza-bicyclo[2.2.1]hept-5-yl ester 

Relevant academic research and scientific papers

DUAL NAV1.2/5HT2A INHIBITORS FOR TREATING CNS DISORDERS

Compounds of formula I: I are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disorders in a patient in need are also disclosed. Such disorders include depression, bipolar disorder, pain, schizophrenia, obsessive compulsive disorder, addiction, social disorder, attention deficit hyperactivity disorder, an anxiety disorder, autism, a cognitive impairment, or a neuropsychiatric symptom such as apathy, depression, anxiety, psychosis, aggression, agitation, impulse control disorders, and sleep disorders in neurological disorders such as Alzheimer's and Parkinson's diseases.

USE OF COMPOSITIONS OBTAINED BY CALCINING PARTICULAR METAL-ACCUMULATING PLANTS FOR IMPLEMENTING CATALYTICAL REACTIONS

The use of metal-accumulating plants for implementing chemical reactions especially catalytical reactions.

Reactivity and selectivity in hydrovinylation of strained alkenes

The scope of Ni(II)-catalyzed hydrovinylation has been extended to strained alkenes such as heterobicyclic [2.2.1]heptanes and cylobutenes. Reactions involving the heterobicyclic compounds are rare examples for this class of compounds where the metal-catalyzed C-C bond-forming reactions proceed without a concomitant ring-opening process. While the enantioselectivity in these systems remains modest, hydrovinylation of endo-5,6 - bis-benzyloxymethylbicyclo[2.2.1] hept-2-ene gives excellent yield (>90%) of the product with one of the highest enantioselectivities (95-99% ee) reported for a C-C bond-forming reaction of norbornenes.

Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists

Orexins are neuropeptides that regulate wakefulness and arousal. Small molecule antagonists of orexin receptors may provide a novel therapy for the treatment of insomnia and other sleep disorders. In this Letter we describe the design and synthesis of con

BRIDGED DIAZEPAN OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to bridged diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. T

Epibatidine alkaloid chemistry: 5. Domino-heck reactions of azabicyclic and tricyclic systems

Palladium-catalyzed hydroarylations and additional domino reactions of azabicyclic and tricyclic norbornene derivatives were investigated and a series of new epibatidine analogues were synthesized.

PIPERAZINO DERIVATIVES AS NEUROKININ ANTAGONISTS

The invention relates to compounds of formula (I) wherein Z, Rc, y, m, u, Ar2, n, X, Rc', l and Ar2 are as described herein. These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.

Stereospecific synthesis of cis-2,4-pyrrolidinedicarboxylic acid and cis-2,5-piperidinedicarboxylic acid

Lactams derived from hetero Diels-Alder adducts were stereospecifically converted into cis-2,4-pyrrolidinedicarboxylic acid and cis-2,5- piperidinedicarboxylic acid by ruthenium tetroxide oxidation. Optically active (2S,4S)-(-)-2,4-pyrrolidinedicarboxylic acid and (2R,4R)-(+)-2,4- pyrrolidinedicarboxylic acid were synthesized from (1S,4R)-(+)-2- azabicyclo[2.2.1]hept-5-en-3-one and (1R,4S)-(-)-2-azabicyclo[2.2.1]hept-5- en-3-one, respectively.

Synthesis and Muscarinic Receptor Activity of Ester Derivatives of 2-Substituted 2-Azabicycloheptan-5-ol and -6-ol

Radioligand binding affinities of four new muscarinic antagonists and six potential muscarinic agonists which possess the 2-alkyl-2-azabicycloheptane ring system have been determined in rat heart, rat brain, and m1- or m3-tran

2-azanorbornadiene

The unstable and hitherto unknown 2-azanorbornadiene 1, interesting example of imine-olefin homoconjugation, has been generated and spectroscopically characterized. Its instability is due to a retro-Diels-Alder reaction which generates cyclopentadiene and hydrogen cyanide.