6671-85-8Relevant articles and documents
DUAL NAV1.2/5HT2A INHIBITORS FOR TREATING CNS DISORDERS
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Paragraph 0177; 0290, (2018/03/28)
Compounds of formula I: I are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disorders in a patient in need are also disclosed. Such disorders include depression, bipolar disorder, pain, schizophrenia, obsessive compulsive disorder, addiction, social disorder, attention deficit hyperactivity disorder, an anxiety disorder, autism, a cognitive impairment, or a neuropsychiatric symptom such as apathy, depression, anxiety, psychosis, aggression, agitation, impulse control disorders, and sleep disorders in neurological disorders such as Alzheimer's and Parkinson's diseases.
Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists
Coleman, Paul J.,Schreier, John D.,McGaughey, Georgia B.,Bogusky, Michael J.,Cox, Christopher D.,Hartman, George D.,Ball, Richard G.,Harrell, C. Meacham,Reiss, Duane R.,Prueksaritanont, Thomayant,Winrow, Christopher J.,Renger, John J.
scheme or table, p. 2311 - 2315 (2010/09/08)
Orexins are neuropeptides that regulate wakefulness and arousal. Small molecule antagonists of orexin receptors may provide a novel therapy for the treatment of insomnia and other sleep disorders. In this Letter we describe the design and synthesis of con
BRIDGED DIAZEPAN OREXIN RECEPTOR ANTAGONISTS
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Page/Page column 29; 30, (2008/06/13)
The present invention is directed to bridged diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. T