647826-69-5Relevant academic research and scientific papers
An efficient synthesis of 5-bromopyridine-2-carbonitrile
Markevitch, David Y.,Rapta, Miroslav,Hecker, Scott J.,Renau, Thomas E.
, p. 3285 - 3289 (2003)
5-Bromopyridine-2-carbonitrile was efficiently synthesized in two steps from 2,5-dibromopyridine with an overall yield of 75%.
ETHYNYL DERIVATIVES AS MODULATORS OF MGLUR5 RECEPTOR ACTIVITY
-
Page/Page column 13, (2014/05/07)
The present invention relates to ethynyl derivatives of formula (I) or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. It has now surprisingly been found that the compounds of general formula (I) are metabotropic glutamate receptor antagonists (negative allosteric modulators) for use in the treatment of anxiety and pain, depression, Fragile-X syndrom, autism spectrum disorders, Parkinson's disease, and gastroesophageal reflux disease (GERD).
PHENYL OR PYRIDINYL-ETHYNYL DERIVATIVES
-
Page/Page column 22-23, (2012/11/07)
The present invention relates to ethynyl derivatives of formula I wherein Y is N or C—R3; R3 is hydrogen, methyl, halogen or nitrile; R1 is phenyl or pyridinyl, each of which is optionally substituted by halogen, lower alk
5-(PHENYL/PYRIDINYL-ETHINYL)-2-PYRIDINE/ 2-PYRIMIDINE-CARBORXAMIDES AS MGLUR5 MODULATORS
-
Page/Page column 29, (2012/11/07)
The present invention relates to ethynyl derivatives of formula (I), wherein, Y is N or C-R3;and R3 is hydrogen, methyl, halogen or nitrile; R1 is phenyl or pyridinyl, which are optionally substituted by halogen, lower alk
