647826-74-2

Upstream product

• 108-98-5 thiophenol 
• 462085-17-2 4,5-dimethoxy-2-{2-[6-(4-methoxy-benzyloxymethyl)-benzo[1,3]dioxol-5-yl]-ethyl}-isoindole-1,3-dione 

Downstream Products

• 647826-77-5 C₂₆H₂₁NO₆S 
• 647826-76-4 C₂₆H₂₃NO₆S 
• 71700-15-7 12b-hydroxy-9,10-dimethoxy-5H-[1,3]dioxolo[4'',5'':4',5']benzo[1',2':4,5]azepino[2,1-a]isoindole-8,13(6H,12bH)-dione 
• 647826-75-3 6-[2-(4,5-dimethoxy-3-oxo-1-phenylsulfanyl-1,3-dihydro-isoindol-2-yl)-ethyl]-benzo[1,3]dioxole-5-carbaldehyde 

Relevant academic research and scientific papers

Lewis acid-promoted tandem desulfurization and hydroxylation of γ-phenylthio-substituted lactams: Novel synthetic strategy of isoindolobenzazepine alkaloid, chilenine

Treatment of a variety of alicyclic and aromatic γ-phenylthio- substituted lactams with Lewis acids such as cuprous or cupric halides in aqueous solution at rt was found to undergo novel tandem desulfurization and hydroxylation reactions to generate γ-hydroxylated lactams without the ring-opened products in extremely high yields, respectively. This process was further applied to the total synthesis of an isoindolobenzazepine alkaloid, chilenine, by featuring the elaboration of the functionalized phthalimide derivative.