462085-17-2

Upstream product

• 4667-74-7 3,4-dimethoxyphthalimide 
• 1026482-49-4 2-[6-(4-methoxy-benzyloxymethyl)-benzo[1,3]dioxol-5-yl]-ethanol 
• 2139-43-7 5-bromo-6-(1,3-dioxolan-2-yl)benzo[d][1,3]dioxolane 
• 99865-52-8 6-(hydroxymethyl)safrole 
• 462085-14-9 5-allyl-6-(4-methoxy-benzyloxymethyl)-benzo[1,3]dioxole 
• 462085-28-5 N-(p-methoxybenzyl) 3,4-dimethoxyphthalimide 
• 123796-70-3 3,4-dimethoxy-2-carbethoxybenzoic acid 
• 462085-12-7 5-allyl-6-[1,3]dioxolan-2-yl-benzo[1,3]dioxole 
• 15930-53-7 6-bromo-3,4-methylenedioxybenzaldehyde 

Downstream Products

• 647826-77-5 C₂₆H₂₁NO₆S 
• 647826-76-4 C₂₆H₂₃NO₆S 
• 647826-75-3 6-[2-(4,5-dimethoxy-3-oxo-1-phenylsulfanyl-1,3-dihydro-isoindol-2-yl)-ethyl]-benzo[1,3]dioxole-5-carbaldehyde 
• 71700-15-7 12b-hydroxy-9,10-dimethoxy-5H-[1,3]dioxolo[4'',5'':4',5']benzo[1',2':4,5]azepino[2,1-a]isoindole-8,13(6H,12bH)-dione 
• 647826-74-2 6,7-dimethoxy-2-{2-[6-(4-methoxy-benzyloxymethyl)-benzo[1,3]dioxol-5-yl]-ethyl}-3-phenylsulfanyl-2,3-dihydro-isoindol-1-one 

Relevant academic research and scientific papers

A novel synthetic approach to isoindolobenzazepine alkaloid, chilenine, employing SmI2-mediated pinacolic coupling reaction

Samarium(II) diiodide-mediated intramolecular reductive coupling reaction of phthalimides with N-formylated alkyl side chains is shown to afford dihydroxylated tricyclic lactams with 5-7-membered rings. This process was further applied for the preparation of an isoindolobenzazepine alkaloid, chilenine, by featuring the elaboration of the functionalized phthalimide derivative.