64785-81-5

Basic information

• Product Name: Pentanoic acid, 5-oxo-5-(phenylamino)-, methyl ester
• CAS NO: 64785-81-5
• Molecular Formula: C12H15NO3
• Molecular Weight: 221.256
• Mol File: 64785-81-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Pentanoic acid, 5-oxo-5-(phenylamino)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Pentanoic acid, 5-oxo-5-(phenylamino)-, methyl ester(64785-81-5)
• EPA Substance Registry System: Pentanoic acid, 5-oxo-5-(phenylamino)-, methyl ester(64785-81-5)

Safety Data

• Hazardous Substances Data: 64785-81-5(Hazardous Substances Data)

Upstream product

• 108-55-4 glutaric anhydride, 
• 62-53-3 aniline 
• 5414-99-3 4-(phenylcarbamoyl)butyric acid 
• 67-56-1 methanol 
• 5768-13-8 N-phenylglutarimide 
• 1501-27-5 Pentanedioic acid, monomethyl ester 
• 1501-26-4 methyl 4-(chlorocarbonyl)butyrate 

Downstream Products

• 1017260-98-8 4-(1H-indol-2-yl)-N-phenylbutanamide 
• 852619-56-8 pentanedioic acid phenylamide (2-tritylsulfanyl-ethyl)-amide 
• 5414-99-3 4-(phenylcarbamoyl)butyric acid 

Relevant articles and documents

Unlocking Amides through Selective C–N Bond Cleavage: Allyl Bromide-Mediated Divergent Synthesis of Nitrogen-Containing Functional Groups

We report a new set of reactions based on the unlocking of amides through simple treatment with allyl bromide, creating a common platform for accessing a diverse range of nitrogen-containing functional groups such as primary amides, sulfonamides, primary amines, N-acyl compounds (esters, thioesters, amides), and N-sulfonyl esters. The method has potential industrial applicability, as demonstrated through gram-scale syntheses in batch and in a continuous flow system.

Antibacterial activity of a novel series of 3-bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives - An extended structure-activity relationship study

Compounds containing 3-bromo-2,5-dihydro-1H-2,5-pyrroledione and indole substructures were found to have antibacterial activity against resistant strains of Staphylococcus aureus and some other Gram positive bacteria. The investigated compounds exhibit mi

Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors

Inhibitors of histone deacetylases (HDAC) are emerging as a promising class of anti-cancer agents. A mercaptoamide functionality was designed as a bidentate zinc chelator and incorporated into the hydroxamic acid based SAHA (1) scaffold in order to identify non-hydroxamate compounds as potential inhibitors of histone deacetylases. Two sets of mercaptoamides 2 and 3 with varying spacer length were synthesized and their HDAC inhibitory activity was evaluated. Low micromolar inhibition was observed for mercaptoamides 2e, 3b, and 3d.