647852-33-3

Upstream product

• 54-42-2 5-Iodo-2'-deoxyuridine 
• 211510-45-1 but-1-yn-4-yl thiobenzoate 
• 151867-57-1 3',5'-bis-O-(tert-butyldimethylsilyl)-C⁵-(4-hydroxy-1-butynyl)-2'-deoxyuridine 
• 148134-86-5 2'-deoxy-3',5'-bis(O-tert-butyldimethylsilyl)-5-iodouridine 
• 98-91-9 thiobenzoic acid 

Downstream Products

• 725735-79-5 5-(4-benzoylthiobut-1-ynyl)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine 
• 647852-36-6 1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-(4-tert-butyldisulfanyl-but-1-ynyl)-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Intrastrand locks increase duplex stability and base pairing selectivity

Oligodeoxynucleotide probes with disulfide locks between neighboring nucleobases show increases in melting point for duplexes with RNA target strands of up to 7.6 °C. The weakly pairing TT dimers are replaced with locked 2′-deoxy-5-(thioalkynyl)uridine re

C-5 Modified nucleosides: Direct insertion of alkynyl-thio functionality in pyrimidines

A route is presented to append, in a single step, alkynyl thioesters to the 5-position of a pyrimidine ring of a nucleoside that is unprotected. These products should be useful to support in vitro selection experiments with functionalized DNA.