647856-30-2

Upstream product

• 100-39-0 benzyl bromide 
• 690264-39-2 4-bromo-2-(trifluoromethoxy)phenol 
• 32858-93-8 2-(trifluoromethoxy)phenol 

Downstream Products

• 1174657-92-1 1-(4-(benzyloxy)-3-(trifluoromethoxy)phenyl)ethanone 
• 1042703-39-8 C₉H₇F₃O₄ 
• 1174657-96-5 4-(2-(4-hydroxy-3-trifluoromethoxyphenyl)-2-oxoethoxy)-4-oxobutan-1-amine trifluoroacetate 
• 1174657-95-4 2-(4-hydroxy-3-(trifluoromethoxy)phenyl)-2-oxoethyl 4-(tert-butoxycarbonylamino)butanoate 
• 1174657-94-3 2-(4-(benzyloxy)-3-(trifluoromethoxy)phenyl)-2-oxoethyl 4-(tert-butoxycarbonylamino)butanoate 
• 1174657-93-2 1-(4-benzyloxy-3-trifluoromethoxyphenyl)-2-bromoethanone 

Relevant academic research and scientific papers

P-Hydroxyphenacyl photoremovable protecting groups Robust photochemistry despite substituent diversity

A broadly based investigation of the effects of a diverse array of substituents on the photochemical rearrangement of p-hydroxyphenacyl esters has demonstrated that common substituents such as F, MeO, CN, CO2R, CONH2, and CH3 have little effect on the rate and quantum efficiencies for the photo-Favorskii rearrangement and the release of the acid leaving group or on the lifetimes of the reactive triplet state. A decrease in the quantum yields across all substituents was observed for the release and rearrangement when the photolyses were carried out in buffered aqueous media at pHs that exceeded the ground-state pKa of the chromophore where the conjugate base is the predominant form. Otherwise, substituents have only a very modest effect on the photoreaction of these robust chromophores.

PYRIMIDINE INHIBITORS OF KINASE ACTIVITY

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G1, R2, R3, R4, R5, n, p, q, Ar1, and Ar2 are defined in the description. The present invention relates also to methods of making said compounds, and compositions comprising said compounds which are useful for inhibiting kinases such as IGF-IR.

Competing pathways in the photo-Favorskii rearrangement and release of esters: Studies on fluorinated p-hydroxyphenacyl-caged GABA and glutamate phototriggers

(Chemical Equation Presented) Three new trifluoromethylated p-hydroxyphenacyl (pHP)-caged γ-aminobutyric acid (GABA) and glutamate (Glu) derivatives have been examined for their efficacy as photoremovable protecting groups in aqueous solution. Through the

N-HYDROXYAMIDE DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY

Novel N-hydroxyamide derivatives are disclosed. These N-hydroxyamide derivatives inhibit UPD-3O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, an enzyme present in gram negative bacteria and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.